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Gene HP1448 from Helicobacter pylori 26695: ribonuclease P, protein component (rnpA)
Member of NCBI Protein Clusters CLSK496496(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899846
UniProtKB accession
RefSeq Protein accession NP_208239.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1448
  • locus tag: HP1448
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction ribonuclease P protein component
Prof. David Horn 3.1.26.5: ribonuclease P / (References: 20034383)
Berkeley Phylogenomics Group 3.1.26.5: Ribonuclease P. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number 3.1.26.5 (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green rnpA from Bacillus subtilis subsp. subtilis str. 168

to see the rest 4 genes click here
GO terms
  • MF: GO:0004518 : nuclease activity : IEA
  • BP: GO:0008033 : tRNA processing : IEA
  • MF: GO:0004519 : endonuclease activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • MF: GO:0000049 : tRNA binding : IEA
  • MF: GO:0004526 : ribonuclease P activity : IEA
  • BP: GO:0001682 : tRNA 5'-leader removal : IEA
  • MF: GO:0003723 : RNA binding : IEA
Domain Structure from CDD
See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
HP1450putative inner membrane protein translocase compon
 
  
HP1449hypothetical protein
 
 
 
HP1446biopolymer transport protein (exbD)
 
  
rpmH50S ribosomal protein L34
 
 
 
mraWS-adenosyl-methyltransferase MraW  
 
trmDtRNA (guanine-N(1)-)-methyltransferase  
 
secEpreprotein translocase membrane subunit  
 
HP0088RNA polymerase sigma factor RpoD  
 
rbfAribosome-binding factor A  
 
nusBtranscription antitermination protein NusB  
 
rplT50S ribosomal protein L20  
 
HP1362replicative DNA helicase  
 
dnaEDNA polymerase III subunit alpha  
 
secApreprotein translocase subunit SecA  
 
ligANAD-dependent DNA ligase LigA  
 
ruvAHolliday junction DNA helicase RuvA  
 
rpsT30S ribosomal protein S20  
 
HP0717DNA polymerase III subunits gamma and tau  
 
HP0955prolipoprotein diacylglyceryl transferase  
 
ruvBHolliday junction DNA helicase RuvB  
 
rplU50S ribosomal protein L21  
 
infCtranslation initiation factor IF-3  
 
rpmE50S ribosomal protein L31  
 
tigtrigger factor  
 
defpeptide deformylase  
 
HP1051hypothetical protein  
 
smpBSsrA-binding protein  
 
lspAlipoprotein signal peptidase  
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)