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Gene HP1448 from Helicobacter pylori 26695: ribonuclease P, protein component (rnpA)
Member of NCBI Protein Clusters CLSK496496(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899846
UniProtKB accession
RefSeq Protein accession NP_208239.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1448
  • locus tag: HP1448
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction ribonuclease P protein component
Prof. David Horn ribonuclease P / (References: 20034383)
Berkeley Phylogenomics Group Ribonuclease P. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green rnpA from Bacillus subtilis subsp. subtilis str. 168

to see the rest 4 genes click here
GO terms
  • MF: GO:0004518 : nuclease activity : IEA
  • BP: GO:0008033 : tRNA processing : IEA
  • MF: GO:0004519 : endonuclease activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • MF: GO:0000049 : tRNA binding : IEA
  • MF: GO:0004526 : ribonuclease P activity : IEA
  • BP: GO:0001682 : tRNA 5'-leader removal : IEA
  • MF: GO:0003723 : RNA binding : IEA
Domain Structure from CDD
See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
HP1450putative inner membrane protein translocase compon
HP1449hypothetical protein
HP1446biopolymer transport protein (exbD)
rpmH50S ribosomal protein L34
mraWS-adenosyl-methyltransferase MraW  
trmDtRNA (guanine-N(1)-)-methyltransferase  
secEpreprotein translocase membrane subunit  
HP0088RNA polymerase sigma factor RpoD  
rbfAribosome-binding factor A  
nusBtranscription antitermination protein NusB  
rplT50S ribosomal protein L20  
HP1362replicative DNA helicase  
dnaEDNA polymerase III subunit alpha  
secApreprotein translocase subunit SecA  
ligANAD-dependent DNA ligase LigA  
ruvAHolliday junction DNA helicase RuvA  
rpsT30S ribosomal protein S20  
HP0717DNA polymerase III subunits gamma and tau  
HP0955prolipoprotein diacylglyceryl transferase  
ruvBHolliday junction DNA helicase RuvB  
rplU50S ribosomal protein L21  
infCtranslation initiation factor IF-3  
rpmE50S ribosomal protein L31  
tigtrigger factor  
defpeptide deformylase  
HP1051hypothetical protein  
smpBSsrA-binding protein  
lspAlipoprotein signal peptidase  
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)