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Gene HP1237 from Helicobacter pylori 26695: carbamoyl phosphate synthase small subunit
Member of NCBI Protein Clusters PRK12564(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899987
UniProtKB accession
RefSeq Protein accession NP_208029.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1237
  • locus tag: HP1237
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction carbamoyl phosphate synthase small subunit
Prof. Vitkup / Confidence:0.783 (References: 19935659, 16507154)
Berkeley Phylogenomics Group Gamma-glutamyl hydrolase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003922 GMP synthase (glutamine-hydrolyzing) activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0033969 gamma-glutamyl-gamma-aminobutyrate hydrolase activity / (References: 19435885)
Berkeley Phylogenomics Group Gamma-glutamyl-gamma-aminobutyrate hydrolase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0019899 enzyme binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003921 GMP synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0034722 gamma-glutamyl-peptidase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green carA from Escherichia coli str. K-12 substr. MG1655
(%_identity=38.68; E_val=3e-71; BitScore=263.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green pyrAA from Bacillus subtilis subsp. subtilis str. 168

to see the rest 3 genes click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0009058 : biosynthetic process : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • MF: GO:0004088 : carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity : IEA
  • BP: GO:0006807 : nitrogen compound metabolic process : IEA
  • BP: GO:0006541 : glutamine metabolic process : IEA
  • BP: GO:0006526 : arginine biosynthetic process : IEA
  • MF: GO:0004086 : carbamoyl-phosphate synthase activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • BP: GO:0006221 : pyrimidine nucleotide biosynthetic process : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
Domain Structure from CDD
  • CPSase_sm_chain: Carbamoyl-phosphate synthase small chain, CPSase domain. The carbamoyl-phosphate synthase domain is in the amino terminu.... (More)
  • PRK12564: carbamoyl phosphate synthase small subunit; Reviewed
  • GATase1_CPSase: Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II. This group of sequences represen.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
domain fusion
HP1235hypothetical protein
HP1236hypothetical protein
carBcarbamoyl phosphate synthase large subunit 
HP0370biotin carboxylase  
pyrBaspartate carbamoyltransferase catalytic subunit  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: CBPS

carbamoyl-phosphate synthase (glutamine-hydrolysing)
2 atp[c] + gln-DASH-L[c] + h2o[c] + hco3[c] -> 2 adp[c] + cbp[c] + glu-DASH-L[c] + 2 h[c] + pi[c]
UTP/CTP de novo Synthesis
Other Genes

Source: Ported to COMBREX by Segre's Lab