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Gene aspS from Helicobacter pylori 26695: aspartyl-tRNA synthetase
Member of NCBI Protein Clusters PRK00476(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899997
UniProtKB accession
RefSeq Protein accession NP_207412.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: aspS
  • locus tag: HP0617
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction aspartyl-tRNA synthetase
Prof. Vitkup / Confidence:0.561 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0004815 aspartate-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group Asparagine--tRNA ligase. / (References: 19435885)
Berkeley Phylogenomics Group Lysine--tRNA ligase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004816 asparagine-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0016597 amino acid binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004824 lysine-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0000049 tRNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003723 RNA binding / (References: 19435885)
Berkeley Phylogenomics Group Aspartate--tRNA ligase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green aspS from Escherichia coli str. K-12 substr. MG1655
(%_identity=49.41; E_val=2e-160; BitScore=560.0)

other hits with E-value < 1e-05
GO terms
  • BP: GO:0006422 : aspartyl-tRNA aminoacylation : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0004815 : aspartate-tRNA ligase activity : IEA
  • MF: GO:0003676 : nucleic acid binding : IEA
  • BP: GO:0006418 : tRNA aminoacylation for protein translation : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0004812 : aminoacyl-tRNA ligase activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
Domain Structure from CDD
  • aspS: aspartyl-tRNA synthetase; Validated
  • AspRS_core: Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of th.... (More)
  • GAD: GAD domain. This domain is found in some members of the GatB and aspartyl tRNA synthetases.
  • class_II_aaRS-like_core: N/A. asparagine synthetase A; Provisional
  • EcAspRS_like_N: EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase .... (More)
  • class_II_aaRS-like_core: Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a comm.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
adkadenylate kinase
HP0616chemotaxis protein (cheV)
rpmA50S ribosomal protein L27 
obgEGTPase ObgE 
HP0559acyl carrier protein (acpP) 
tsfelongation factor Ts 
mnmAtRNA-specific 2-thiouridylase MnmA 
HP0745hypothetical protein 
HP0956hypothetical protein 
HP1069cell division protein (ftsH) 
frrribosome recycling factor 
rplS50S ribosomal protein L19 
HP0013hypothetical protein 
HP0347hypothetical protein 
rpsP30S ribosomal protein S16 
tufelongation factor Tu 
rpsR30S ribosomal protein S18 
HP0962acyl carrier protein (acpP) 
HP1245single-stranded DNA-binding protein 
rpsF30S ribosomal protein S6 
rplQ50S ribosomal protein L17 
rpmG50S ribosomal protein L33 
prfApeptide chain release factor 1 
HP1497peptidyl-tRNA hydrolase 
HP0355GTP-binding protein LepA 
HP1450putative inner membrane protein translocase compon 
rplI50S ribosomal protein L9 
HP0286cell division protein (ftsH) 
rpmI50S ribosomal protein L35 
rplL50S ribosomal protein L7/L12 
rncribonuclease III 
fmtmethionyl-tRNA formyltransferase