Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene aspS from Helicobacter pylori 26695: aspartyl-tRNA synthetase
Member of NCBI Protein Clusters PRK00476(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899997
UniProtKB accession
RefSeq Protein accession NP_207412.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: aspS
  • locus tag: HP0617
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction aspartyl-tRNA synthetase
Prof. Vitkup 6.1.1.12 / Confidence:0.561 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0004815 aspartate-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group 6.1.1.22: Asparagine--tRNA ligase. / (References: 19435885)
Berkeley Phylogenomics Group 6.1.1.6: Lysine--tRNA ligase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004816 asparagine-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0016597 amino acid binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004824 lysine-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0000049 tRNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003723 RNA binding / (References: 19435885)
Berkeley Phylogenomics Group 6.1.1.12: Aspartate--tRNA ligase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green aspS from Escherichia coli str. K-12 substr. MG1655
(%_identity=49.41; E_val=2e-160; BitScore=560.0)

other hits with E-value < 1e-05
GO terms
  • BP: GO:0006422 : aspartyl-tRNA aminoacylation : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0004815 : aspartate-tRNA ligase activity : IEA
  • MF: GO:0003676 : nucleic acid binding : IEA
  • BP: GO:0006418 : tRNA aminoacylation for protein translation : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0004812 : aminoacyl-tRNA ligase activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
Domain Structure from CDD
  • aspS: aspartyl-tRNA synthetase; Validated
  • AspRS_core: Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of th.... (More)
  • GAD: GAD domain. This domain is found in some members of the GatB and aspartyl tRNA synthetases.
  • class_II_aaRS-like_core: N/A. asparagine synthetase A; Provisional
  • EcAspRS_like_N: EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase .... (More)
  • class_II_aaRS-like_core: Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a comm.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
phylogenetic profile
adkadenylate kinase
 
 
HP0616chemotaxis protein (cheV)
 
 
rpmA50S ribosomal protein L27 
 
obgEGTPase ObgE 
 
HP0559acyl carrier protein (acpP) 
 
tsfelongation factor Ts 
 
mnmAtRNA-specific 2-thiouridylase MnmA 
 
HP0745hypothetical protein 
 
HP0956hypothetical protein 
 
HP1069cell division protein (ftsH) 
 
frrribosome recycling factor 
 
rplS50S ribosomal protein L19 
 
HP0013hypothetical protein 
 
HP0347hypothetical protein 
 
rpsP30S ribosomal protein S16 
 
tufelongation factor Tu 
 
rpsR30S ribosomal protein S18 
 
HP0962acyl carrier protein (acpP) 
 
HP1245single-stranded DNA-binding protein 
 
rpsF30S ribosomal protein S6 
 
rplQ50S ribosomal protein L17 
 
rpmG50S ribosomal protein L33 
 
prfApeptide chain release factor 1 
 
HP1497peptidyl-tRNA hydrolase 
 
HP0355GTP-binding protein LepA 
 
HP1450putative inner membrane protein translocase compon 
 
rplI50S ribosomal protein L9 
 
HP0286cell division protein (ftsH) 
 
rpmI50S ribosomal protein L35 
 
rplL50S ribosomal protein L7/L12 
 
rncribonuclease III 
 
fmtmethionyl-tRNA formyltransferase