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Gene gltX from Helicobacter pylori 26695: glutamylglutaminyl-tRNA synthetase
Member of NCBI Protein Clusters PRK12410(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900020
UniProtKB accession
RefSeq Protein accession NP_207437.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: gltX
  • locus tag: HP0643
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction glutamylglutaminyl-tRNA synthetase
Prof. Vitkup / Confidence:0.606 (References: 19935659, 16507154)
Source References Functional description
[PMID: 13679580]
[PMID: 14615592]
GlutamylGlutaminyl-tRNA synthetase (source organism: Helicobacter pylori (Campylobacter pylori).; strain specific ID: ATCC 700392 / 26695)
Functional Status greenGreen (experimental evidence, uncurated)
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • MF: GO:0004818 : glutamate-tRNA ligase activity : IEA
  • BP: GO:0006412 : translation : IEA
  • BP: GO:0006418 : tRNA aminoacylation for protein translation : IEA
  • BP: GO:0006424 : glutamyl-tRNA aminoacylation : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0004812 : aminoacyl-tRNA ligase activity : IEA
Domain Structure from CDD
  • nt_trans: nucleotidyl transferase superfamily. CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the condensation of CTP and.... (More)
  • GluRS_core: catalytic core domain of descriminating glutamyl-tRNA synthetase. Descriminating Glutamyl-tRNA synthetase (GluRS) cataly.... (More)
  • nt_trans: nucleotidyl transferase superfamily. nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl.... (More)
  • PRK12410: glutamylglutaminyl-tRNA synthetase; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
gltX (3) , HPAG1_0628 , HPG27_605 , HPSH_03645
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP0644hypothetical protein
HP0645soluble lytic murein transglycosylase (slt)
HP0642NAD(P)H-flavin oxidoreductase
Metabolic Annotation from Palsson Lab

Metabolic Reaction: GLUTRS

Glutamyl-tRNA synthetase
atp[c] + glu-DASH-L[c] + trnaglu[c] -> amp[c] + glutrna[c] + ppi[c]
Heme biosynthesis
Other Genes

Source: Ported to COMBREX by Segre's Lab