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Gene dnaK from Helicobacter pylori 26695: molecular chaperone DnaK
Member of NCBI Protein Clusters PRK00290(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900161
UniProtKB accession
RefSeq Protein accession NP_206909.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: dnaK
  • locus tag: HP0109
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction molecular chaperone DnaK
Prof. Vitkup 6.1.1.4 / Confidence:0.01 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0043027 caspase inhibitor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0051082 unfolded protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0030234 enzyme regulator activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0016887 ATPase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042623 ATPase activity, coupled / (References: 19435885)
Berkeley Phylogenomics Group GO:0051787 misfolded protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0051087 chaperone binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019904 protein domain specific binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043022 ribosome binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005516 calmodulin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042277 peptide binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0031625 ubiquitin protein ligase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0051059 NF-kappaB binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0002020 protease binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green dnaK from Coxiella burnetii RSA 493
(%_identity=59.8; E_val=0.0; BitScore=723.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green hscC from Escherichia coli str. K-12 substr. MG1655

to see the rest 4 genes click here
GO terms
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0051082 : unfolded protein binding : IEA
  • BP: GO:0006457 : protein folding : IEA
  • BP: GO:0006950 : response to stress : IEA
  • MF: GO:0005524 : ATP binding : IEA
Domain Structure from CDD
  • dnaK: molecular chaperone DnaK; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
HP0110co-chaperone and heat shock protein (grpE)
 
 
 
HP0111heat-inducible transcription repressor
 
  
HP1332co-chaperone and heat shock protein (dnaJ)  
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)