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Gene gmk from Helicobacter pylori 26695: guanylate kinase
Member of NCBI Protein Clusters PRK00300(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900200
UniProtKB accession
RefSeq Protein accession NP_207119.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: gmk
  • locus tag: HP0321
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction guanylate kinase
Prof. Vitkup 2.7.4.8 / Confidence:0.755 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0008013 beta-catenin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004683 calmodulin-dependent protein kinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005102 receptor binding / (References: 19435885)
Berkeley Phylogenomics Group 2.7.11.17: Calcium/calmodulin-dependent protein kinase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019901 protein kinase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042043 neurexin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008022 protein C-terminus binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008092 cytoskeletal protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0035255 ionotropic glutamate receptor binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0030165 PDZ domain binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0032947 protein complex scaffold / (References: 19435885)
Berkeley Phylogenomics Group GO:0004385 guanylate kinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0019902 phosphatase binding / (References: 19435885)
Berkeley Phylogenomics Group 2.7.11.1: Non-specific serine/threonine protein kinase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0032403 protein complex binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0046982 protein heterodimerization activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green gmk from Synechocystis sp. PCC 6803
(%_identity=44.38; E_val=9e-37; BitScore=148.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green gmk from Haemophilus influenzae Rd KW20

to see the rest 4 genes click here
GO terms
  • MF: GO:0000166 : nucleotide binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0006163 : purine nucleotide metabolic process : IEA
  • MF: GO:0016301 : kinase activity : IEA
  • MF: GO:0004385 : guanylate kinase activity : IEA
  • MF: GO:0016740 : transferase activity : IEA
Domain Structure from CDD
  • GMPK: Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phos.... (More)
  • Adk: Adenylate kinase and related kinases [Nucleotide transport and metabolism]

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
HP0322poly E-rich protein
 
argSarginyl-tRNA synthetase
 
HP0320hypothetical protein
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: DGK1

Name
deoxyguanylate kinase (dGMP:ATP)
Formula
atp[c] + dgmp[c] <=> adp[c] + dgdp[c]
Pathway
Nucleotide Interconversion

Metabolic Reaction: GK1

Name
guanylate kinase (GMP:ATP)
Formula
atp[c] + gmp[c] <=> adp[c] + gdp[c]
Pathway
GTP de novo Synthesis

Source: Ported to COMBREX by Segre's Lab
KEGG
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)