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Gene HP1260 from Helicobacter pylori 26695: NADH dehydrogenase subunit A

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Summary
Member of NCBI Protein Clusters PRK08489(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900263
UniProtKB accession
RefSeq Protein accession NP_208052.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1260
  • locus tag: HP1260
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)

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Actions You Can Take
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).

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Function Predictions
Source Predicted function(s)
NCBI Protein Cluster Prediction NADH dehydrogenase subunit A
Prof. Vitkup 1.6.5.3 / Confidence:0.504 (References: 19935659, 16507154)

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Supporting Functional Information
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green nuoA from Rhodobacter capsulatus

to see the rest 4 genes click here
GO terms
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0050136 : NADH dehydrogenase (quinone) activity : IEA
  • MF: GO:0048038 : quinone binding : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0008137 : NADH dehydrogenase (ubiquinone) activity : IEA
Domain Structure from CDD
  • Oxidored_q4: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3. NADH dehydrogenase subunit A; Validated

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database

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Functionally Linked Genes
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
HP1262NADH dehydrogenase subunit C
 
 
 
HP1258hypothetical protein
 
  
HP1259hypothetical protein
 
  
HP1261NADH dehydrogenase subunit B
 
 
 
HP1267NADH dehydrogenase subunit H  
 
HP1269NADH dehydrogenase subunit J  
 
HP1270NADH dehydrogenase subunit K  
 
HP1272NADH dehydrogenase subunit M  
 
HP1268NADH dehydrogenase subunit I  
 
HP1273NADH dehydrogenase subunit N  
 
HP1263NADH dehydrogenase subunit D  
 

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Pathway Information
Metabolic Annotation from Palsson Lab

Metabolic Reaction: NDH_1

Name
NADH dehydrogenase (menaquinone) (complex I)
Formula
3 h[c] + mqn6[c] + nadph[c] -> 2 h[e] + mql6[c] + nadp[c]
Pathway
Respiratory chain
Other Genes

Source: Ported to COMBREX by Segre's Lab
KEGG