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Gene HP0355 from Helicobacter pylori 26695: GTP-binding protein LepA
Member of NCBI Protein Clusters PRK05433(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900304
UniProtKB accession
RefSeq Protein accession NP_207153.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0355
  • locus tag: HP0355
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction GTP-binding protein LepA
Prof. Vitkup / Confidence:0.002 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0004888 transmembrane receptor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042803 protein homodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0030234 enzyme regulator activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003924 GTPase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043022 ribosome binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0032947 protein complex scaffold / (References: 19435885)
Berkeley Phylogenomics Group GO:0005545 phosphatidylinositol binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005525 GTP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0031625 ubiquitin protein ligase binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
GO terms
  • MF: GO:0005525 : GTP binding : IEA
  • MF: GO:0003924 : GTPase activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
Domain Structure from CDD
  • lepA_C: lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membran.... (More)
  • PRK05433: GTP-binding protein LepA; Provisional
  • Translation_Factor_II_like: N/A. Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta bar.... (More)
  • LepA: LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G .... (More)
  • LepA_C: GTP-binding protein LepA C-terminus. This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins.

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP0356hypothetical protein
fliHflagellar assembly protein H
HP03541-deoxy-D-xylulose-5-phosphate synthase
HP1497peptidyl-tRNA hydrolase 
rpmI50S ribosomal protein L35 
rplI50S ribosomal protein L9 
HP0956hypothetical protein 
tufelongation factor Tu 
HP0013hypothetical protein 
mnmAtRNA-specific 2-thiouridylase MnmA 
HP0559acyl carrier protein (acpP) 
rpsP30S ribosomal protein S16 
HP0286cell division protein (ftsH) 
fmtmethionyl-tRNA formyltransferase 
rpsF30S ribosomal protein S6 
frrribosome recycling factor 
tsfelongation factor Ts 
aspSaspartyl-tRNA synthetase 
rplQ50S ribosomal protein L17 
HP0745hypothetical protein 
HP1245single-stranded DNA-binding protein 
obgEGTPase ObgE 
HP0962acyl carrier protein (acpP) 
rncribonuclease III 
rplS50S ribosomal protein L19 
HP1069cell division protein (ftsH) 
rpsR30S ribosomal protein S18 
rplL50S ribosomal protein L7/L12 
HP0347hypothetical protein 
rpmA50S ribosomal protein L27 
HP1450putative inner membrane protein translocase compon 
rpmG50S ribosomal protein L33 
prfApeptide chain release factor 1