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Functional Status	blue (function predicted, no experimental evidence)
Source of prediction	NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins	This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
GO terms	MF: GO:0005525 : GTP binding : IEA MF: GO:0003924 : GTPase activity : IEA MF: GO:0000166 : nucleotide binding : IEA
Domain Structure from CDD	lepA_C: lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits significant homology to elongation factors (EFs) Tu and G. The function(s) of the proteins in this family are unknown. The N-terminal domain of LepA is homologous to a domain of similar size found in initiation factor 2 (IF2), and in EF-Tu and EF-G (factors required for translation in Escherichia coli). Two types of phylogenetic tree, rooted by other GTP-binding proteins, suggest that eukaryotic homologs (including S. cerevisiae GUF1) originated within the bacterial LepA family. LepA has never been observed in archaea, and eukaryl LepA is organellar. LepA is therefore a true bacterial GTPase, found only in the bacterial lineage..... (More) PRK05433: GTP-binding protein LepA; Provisional Translation_Factor_II_like: N/A. Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to pfam03143, and in fact has weak sequence matches to this domain..... (More) LepA: LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and eukaryota (e.g. yeast GUF1p), but is missing from archaea. This pattern of phyletic distribution suggests that LepA evolved through a duplication of the EF-G gene in bacteria, followed by early transfer into the eukaryotic lineage, most likely from the promitochondrial endosymbiont. Yeast GUF1p is not essential and mutant cells did not reveal any marked phenotype..... (More) LepA_C: GTP-binding protein LepA C-terminus. This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins. See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	EFG_C H GTP_EFTU H GTP_EFTU_D2 H LepA_C H See domain structure on Pfam Database

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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com

HP0356 hypothetical protein     fliH flagellar assembly protein H     HP0354 1-deoxy-D-xylulose-5-phosphate synthase     HP1497 peptidyl-tRNA hydrolase     rpmI 50S ribosomal protein L35     rplI 50S ribosomal protein L9     HP0956 hypothetical protein     tuf elongation factor Tu     HP0013 hypothetical protein     mnmA tRNA-specific 2-thiouridylase MnmA     HP0559 acyl carrier protein (acpP)     rpsP 30S ribosomal protein S16     HP0286 cell division protein (ftsH)     fmt methionyl-tRNA formyltransferase     rpsF 30S ribosomal protein S6     frr ribosome recycling factor     tsf elongation factor Ts     aspS aspartyl-tRNA synthetase     rplQ 50S ribosomal protein L17     HP0745 hypothetical protein     HP1245 single-stranded DNA-binding protein     obgE GTPase ObgE     HP0962 acyl carrier protein (acpP)     rnc ribonuclease III     rplS 50S ribosomal protein L19     HP1069 cell division protein (ftsH)     rpsR 30S ribosomal protein S18     rplL 50S ribosomal protein L7/L12     HP0347 hypothetical protein     rpmA 50S ribosomal protein L27     HP1450 putative inner membrane protein translocase compon     rpmG 50S ribosomal protein L33     prfA peptide chain release factor 1