Gene HP0355 from Helicobacter pylori 26695: GTP-binding protein LepA
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Member of NCBI Protein Clusters
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PRK05433(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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900304
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UniProtKB accession
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RefSeq Protein accession
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NP_207153.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: HP0355
- locus tag: HP0355
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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BLASTP hits to experimentally validated proteins
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This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
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GO terms
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MF:
GO:0005525 : GTP binding : IEA
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MF:
GO:0003924 : GTPase activity : IEA
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MF:
GO:0000166 : nucleotide binding : IEA
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Domain Structure from CDD
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- lepA_C: lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits significant homology to elongation factors (EFs) Tu and G. The function(s) of the proteins in this family are unknown. The N-terminal domain of LepA is homologous to a domain of similar size found in initiation factor 2 (IF2), and in EF-Tu and EF-G (factors required for translation in Escherichia coli). Two types of phylogenetic tree, rooted by other GTP-binding proteins, suggest that eukaryotic homologs (including S. cerevisiae GUF1) originated within the bacterial LepA family. LepA has never been observed in archaea, and eukaryl LepA is organellar. LepA is therefore a true bacterial GTPase, found only in the bacterial lineage..... (More)
- PRK05433: GTP-binding protein LepA; Provisional
- Translation_Factor_II_like: N/A. Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to pfam03143, and in fact has weak sequence matches to this domain..... (More)
- LepA: LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and eukaryota (e.g. yeast GUF1p), but is missing from archaea. This pattern of phyletic distribution suggests that LepA evolved through a duplication of the EF-G gene in bacteria, followed by early transfer into the eukaryotic lineage, most likely from the promitochondrial endosymbiont. Yeast GUF1p is not essential and mutant cells did not reveal any marked phenotype..... (More)
- LepA_C: GTP-binding protein LepA C-terminus. This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins.
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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 | HP0356 | hypothetical protein | | | fliH | flagellar assembly protein H | | | HP0354 | 1-deoxy-D-xylulose-5-phosphate synthase | | | HP1497 | peptidyl-tRNA hydrolase | | | rpmI | 50S ribosomal protein L35 | | | rplI | 50S ribosomal protein L9 | | | HP0956 | hypothetical protein | | | tuf | elongation factor Tu | | | HP0013 | hypothetical protein | | | mnmA | tRNA-specific 2-thiouridylase MnmA | | | HP0559 | acyl carrier protein (acpP) | | | rpsP | 30S ribosomal protein S16 | | | HP0286 | cell division protein (ftsH) | | | fmt | methionyl-tRNA formyltransferase | | | rpsF | 30S ribosomal protein S6 | | | frr | ribosome recycling factor | | | tsf | elongation factor Ts | | | aspS | aspartyl-tRNA synthetase | | | rplQ | 50S ribosomal protein L17 | | | HP0745 | hypothetical protein | | | HP1245 | single-stranded DNA-binding protein | | | obgE | GTPase ObgE | | | HP0962 | acyl carrier protein (acpP) | | | rnc | ribonuclease III | | | rplS | 50S ribosomal protein L19 | | | HP1069 | cell division protein (ftsH) | | | rpsR | 30S ribosomal protein S18 | | | rplL | 50S ribosomal protein L7/L12 | | | HP0347 | hypothetical protein | | | rpmA | 50S ribosomal protein L27 | | | HP1450 | putative inner membrane protein translocase compon | | | rpmG | 50S ribosomal protein L33 | | | prfA | peptide chain release factor 1 | | |
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