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Gene HP1245 from Helicobacter pylori 26695: single-stranded DNA-binding protein
Member of NCBI Protein Clusters PRK08486(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900340
UniProtKB accession
RefSeq Protein accession NP_208037.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1245
  • locus tag: HP1245
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB: 2VW9
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction single-stranded DNA-binding protein
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003697 single-stranded DNA binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green ssbB from Bacillus subtilis subsp. subtilis str. 168

to see the rest 7 genes click here
GO terms
  • BP: GO:0006260 : DNA replication : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • BP: GO:0006974 : response to DNA damage stimulus : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • MF: GO:0003697 : single-stranded DNA binding : IEA
Domain Structure from CDD
  • SSB_OBF: SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
rpsF30S ribosomal protein S6
 
 
 
HP1247DNA polymerase III subunit delta
 
  
rpsR30S ribosomal protein S18
 
 
 
HP1243outer membrane protein (omp28)
 
  
HP1497peptidyl-tRNA hydrolase  
 
tufelongation factor Tu  
 
HP0013hypothetical protein  
 
mnmAtRNA-specific 2-thiouridylase MnmA  
 
rpsP30S ribosomal protein S16  
 
HP0286cell division protein (ftsH)  
 
fmtmethionyl-tRNA formyltransferase  
 
HP0956hypothetical protein  
 
HP0559acyl carrier protein (acpP)  
 
aspSaspartyl-tRNA synthetase  
 
rplQ50S ribosomal protein L17  
 
HP0745hypothetical protein  
 
tsfelongation factor Ts  
 
HP0962acyl carrier protein (acpP)  
 
rncribonuclease III  
 
rplS50S ribosomal protein L19  
 
HP1069cell division protein (ftsH)  
 
rplL50S ribosomal protein L7/L12  
 
HP0347hypothetical protein  
 
rpmA50S ribosomal protein L27  
 
HP1450putative inner membrane protein translocase compon  
 
rpmG50S ribosomal protein L33  
 
frrribosome recycling factor  
 
HP0355GTP-binding protein LepA  
 
obgEGTPase ObgE  
 
rpmI50S ribosomal protein L35  
 
rplI50S ribosomal protein L9  
 
prfApeptide chain release factor 1  
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)