Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
Genes with solved structures in PDB
Genes with Pfam domains shared with human proteins
Genes with products purified by PSI
Genes cloned by PSI
close options


Gene HP1245 from Helicobacter pylori 26695: single-stranded DNA-binding protein
Member of NCBI Protein Clusters PRK08486(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900340
UniProtKB accession
RefSeq Protein accession NP_208037.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1245
  • locus tag: HP1245
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB: 2VW9
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction single-stranded DNA-binding protein
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003697 single-stranded DNA binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green ssbB from Bacillus subtilis subsp. subtilis str. 168

to see the rest 7 genes click here
GO terms
  • BP: GO:0006260 : DNA replication : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • BP: GO:0006974 : response to DNA damage stimulus : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • MF: GO:0003697 : single-stranded DNA binding : IEA
Domain Structure from CDD
  • SSB_OBF: SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
rpsF30S ribosomal protein S6
HP1247DNA polymerase III subunit delta
rpsR30S ribosomal protein S18
HP1243outer membrane protein (omp28)
HP1497peptidyl-tRNA hydrolase  
tufelongation factor Tu  
HP0013hypothetical protein  
mnmAtRNA-specific 2-thiouridylase MnmA  
rpsP30S ribosomal protein S16  
HP0286cell division protein (ftsH)  
fmtmethionyl-tRNA formyltransferase  
HP0956hypothetical protein  
HP0559acyl carrier protein (acpP)  
aspSaspartyl-tRNA synthetase  
rplQ50S ribosomal protein L17  
HP0745hypothetical protein  
tsfelongation factor Ts  
HP0962acyl carrier protein (acpP)  
rncribonuclease III  
rplS50S ribosomal protein L19  
HP1069cell division protein (ftsH)  
rplL50S ribosomal protein L7/L12  
HP0347hypothetical protein  
rpmA50S ribosomal protein L27  
HP1450putative inner membrane protein translocase compon  
rpmG50S ribosomal protein L33  
frrribosome recycling factor  
HP0355GTP-binding protein LepA  
obgEGTPase ObgE  
rpmI50S ribosomal protein L35  
rplI50S ribosomal protein L9  
prfApeptide chain release factor 1  
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)