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Gene HP1348 from Helicobacter pylori 26695: 1-acyl-glycerol-3-phosphate acyltransferase (plsC)

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Summary
Member of NCBI Protein Clusters CLSK872541(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900355
UniProtKB accession
RefSeq Protein accession NP_208140.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1348
  • locus tag: HP1348
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)

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Actions You Can Take
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).

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Function Predictions
Source Predicted function(s)
NCBI Protein Cluster Prediction 1-acyl-sn-glycerol-3-phosphate acyltransferase
Prof. Vitkup 2.3.1.51 / Confidence:0.165 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042171 lysophosphatidic acid acyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group 2.3.1.51: 1-acylglycerol-3-phosphate O-acyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0046027 phospholipid:diacylglycerol acyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004366 glycerol-3-phosphate O-acyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group 2.3.1.67: 1-alkylglycerophosphocholine O-acetyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group 2.3.1.23: 1-acylglycerophosphocholine O-acyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008415 acyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group 2.3.1.40: Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0008779 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity / (References: 19435885)

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Supporting Functional Information
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number 2.3.1.51 (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green plsD from Clostridium butyricum

to see the rest 4 genes click here
GO terms
  • MF: GO:0008415 : acyltransferase activity : IEA
  • CC: GO:0016020 : membrane : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • MF: GO:0003841 : 1-acylglycerol-3-phosphate O-acyltransferase activity : IEA
  • BP: GO:0008654 : phospholipid biosynthetic process : IEA
Domain Structure from CDD
  • LPLAT_AGPAT-like: Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransfe.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database

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Functionally Linked Genes
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
phylogenetic profile
HP1350protease
 
 
HP1349hypothetical protein
 
 
HP1346glyceraldehyde-3-phosphate dehydrogenase
 
 
HP1347uracil-DNA glycosylase
 
 
HP0347hypothetical protein 
 
HP0956hypothetical protein 
 
HP0745hypothetical protein 
 

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Pathway Information
Metabolic Annotation from Palsson Lab

Metabolic Reaction: PASYN_HP

Name
Phosphatidic acid synthase Hp specific
Formula
c190cACP[c] + glyc3p[c] + myrsACP[c] -> 2 ACP[c] + pa-Hp[c]
Pathway
Glycerolipid Synthesis

Source: Ported to COMBREX by Segre's Lab
KEGG

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Phenotype data
Phenotype Description Expression
Class		 Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)