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Gene amiF from Helicobacter pylori 26695: formamidase
Member of NCBI Protein Clusters PRK13287(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900367
UniProtKB accession
RefSeq Protein accession NP_208030.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: amiF
  • locus tag: HP1238
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB: 2DYU 2DYV 2E2K 2E2L
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction formamidase
Prof. Vitkup 3.5.1.49 / Confidence:0.607 (References: 19935659, 16507154)
Berkeley Phylogenomics Group 3.5.5.1: Nitrilase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0047558 3-cyanoalanine hydratase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0018822 nitrile hydratase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003837 beta-ureidopropionase activity / (References: 19435885)
Berkeley Phylogenomics Group 3.5.1.4: Amidase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0047427 cyanoalanine nitrilase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group 3.5.5.5: Arylacetonitrilase. / (References: 19435885)
Berkeley Phylogenomics Group 4.2.1.66: Cyanide hydratase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0047710 bis(5'-adenosyl)-triphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0050126 N-carbamoylputrescine amidase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0080109 indole-3-acetonitrile nitrile hydratase activity / (References: 19435885)
Berkeley Phylogenomics Group 3.5.5.7: Aliphatic nitrilase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0017159 pantetheine hydrolase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0080061 indole-3-acetonitrile nitrilase activity / (References: 19435885)
Source References Functional description
GSDB
[PMID: 11359566]
[PMID: 12499381]
Formamidase (source organism: Helicobacter pylori (Campylobacter pylori).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • MF: GO:0004328 : formamidase activity : IEA
  • BP: GO:0006807 : nitrogen compound metabolic process : IEA
  • MF: GO:0016810 : hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • COG0388: Predicted amidohydrolase [General function prediction only]
  • aliphatic_amidase: aliphatic amidases (class 2 nitrilases). Aliphatic amidases catalyze the hydrolysis of short-chain aliphatic amides to f.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
amiF (6)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
HP1236hypothetical protein
 
HP1237carbamoyl phosphate synthase small subunit
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: FORAMD

Name
formamidase
Formula
frmd[c] + h2o[c] -> for[c] + nh4[c]
Pathway
Others

Source: Ported to COMBREX by Segre's Lab
KEGG