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Gene grpE from Bacillus subtilis subsp. subtilis str. 168: nucleotide exchange factor for DnaK activity
Member of NCBI Protein Clusters PRK14140(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 937846
UniProtKB accession
RefSeq Protein accession NP_390426.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: grpE
  • locus tag: BSU25480
Organism Bacillus subtilis subsp. subtilis str. 168 (NCBI TaxID: 224308)
Other Cross References:
  • S
    Structure(s) available in PDB: 2G61
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Source Predicted function(s)
NCBI Protein Cluster Prediction heat shock protein GrpE
Source References Functional description
GSDB Under Review protein grpE (source organism: Bacillus subtilis; strain specific ID: NCBI_TaxID=1423)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0030150 : protein import into mitochondrial matrix : IEA
  • CC: GO:0005739 : mitochondrion : IEA
  • MF: GO:0051087 : chaperone binding : IEA
  • MF: GO:0005515 : protein binding : IEA
  • MF: GO:0042803 : protein homodimerization activity : IEA
  • MF: GO:0000774 : adenyl-nucleotide exchange factor activity : IEA
  • BP: GO:0006457 : protein folding : IEA
  • BP: GO:0006950 : response to stress : IEA
  • CC: GO:0005737 : cytoplasm : IEA
Domain Structure from CDD
  • GrpE: GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain o.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
grpE