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Gene dnaJ from Escherichia coli str. K-12 substr. MG1655: chaperone Hsp40, co-chaperone with DnaK
Member of NCBI Protein Clusters PRK10767(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 944753
UniProtKB accession
RefSeq Protein accession NP_414556.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: dnaJ
  • locus tag: b0015
  • aliases: ECK0015, JW0014, groP, grpC
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction chaperone protein DnaJ
Source References Functional description
GSDB
[PMID: 3003084]
[PMID: 1826368]
[PMID: 15302880]
[PMID: 8106526]
[PMID: 9860950]
[PMID: 12454054]
[PMID: 12941935]
[PMID: 15683252]
[PMID: 8764403]
[PMID: 10210198]
[PMID: 10891270]
Chaperone protein dnaJ (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • MF: GO:0031072 : heat shock protein binding : IEA
  • CC: GO:0005624 : membrane fraction : IDA
  • MF: GO:0008270 : zinc ion binding : IMP
  • MF: GO:0008270 : zinc ion binding : IEA
  • BP: GO:0006457 : protein folding : IDA
  • MF: GO:0008270 : zinc ion binding : IDA
  • MF: GO:0042803 : protein homodimerization activity : IDA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0042026 : protein refolding : IDA
  • MF: GO:0051082 : unfolded protein binding : IEA
  • BP: GO:0006950 : response to stress : IEA
  • MF: GO:0003756 : protein disulfide isomerase activity : IDA
  • BP: GO:0009408 : response to heat : IEP
  • MF: GO:0005515 : protein binding : IPI
  • BP: GO:0006260 : DNA replication : IEA
  • MF: GO:0051082 : unfolded protein binding : IDA
  • BP: GO:0006260 : DNA replication : IMP
  • BP: GO:0009408 : response to heat : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • CC: GO:0005737 : cytoplasm : IDA
  • BP: GO:0006457 : protein folding : IEA
  • MF: GO:0005515 : protein binding : IMP
Domain Structure from CDD
  • PRK10767: chaperone protein DnaJ; Provisional
  • DnaJ_C: DnaJ C terminal region. This family consists of the C terminal region form the DnaJ protein. Although the function of th.... (More)
  • DnaJ: DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in pro.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03371 , dnaJ (51) , dnaJ2 , EcolC_3641 , ECP_0015 , ECs0015 , ECSE_0014 , Ent638_0579 , ESA_03324 , NT01EI_0673 , SARI_02979 , SG0410 , SPAB_00015 , Spro_0693 , SSPA0012 , YPA_4063 , YPDSF_3162 , YPK_3593 , YPN_0342 , YPTS_0636
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 gene neighbourhoods
phylogenetic profile
domain fusion
dnaKchaperone Hsp70, co-chaperone with DnaJ
 
 
 
yegDpredicted chaperone 
 
 
hscADnaK-like molecular chaperone specific for IscU 
 
 
hscCHsp70 family chaperone Hsc62, binds to RpoD and in 
 
 
trxAthioredoxin 1  
 
Phenotype Description Expression
Class
Reference(s)
Nitrofurantoin sensitivity Knockout confers increased sensitivity to nitrofurantoin Knock out
PMID: 20065048
Triclosan sensitivity Knockout confers increased sensitivity to triclosan Knock out
PMID: 20065048