Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
Genes with solved structures in PDB
Genes with Pfam domains shared with human proteins
Genes with products purified by PSI
Genes cloned by PSI
close options


Gene ispU from Escherichia coli str. K-12 substr. MG1655: undecaprenyl pyrophosphate synthase
Member of NCBI Protein Clusters PRK10240(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 944874
UniProtKB accession
RefSeq Protein accession NP_414716.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ispU
  • locus tag: b0174
  • aliases: ECK0173, JW0169, rth, uppS, yaeS
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction undecaprenyl pyrophosphate synthase
Source References Functional description
[PMID: 9882662]
[PMID: 10217761]
[PMID: 11076526]
[PMID: 11744728]
[PMID: 11581264]
[PMID: 12756244]
Undecaprenyl pyrophosphate synthase (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • BP: GO:0016094 : polyprenol biosynthetic process : IDA
  • MF: GO:0008834 : di-trans,poly-cis-decaprenylcistransferase activity : IEA
  • BP: GO:0007049 : cell cycle : IEA
  • CC: GO:0005737 : cytoplasm : IDA
  • MF: GO:0016765 : transferase activity, transferring alkyl or aryl (other than methyl) groups : IEA
  • MF: GO:0008834 : di-trans,poly-cis-decaprenylcistransferase activity : IDA
  • MF: GO:0016740 : transferase activity : IEA
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • BP: GO:0051301 : cell division : IEA
  • BP: GO:0007047 : cellular cell wall organization : IEA
Domain Structure from CDD
  • CIS_IPPS: Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the is.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
APECO1_1813 , CKO_03192 , EcolC_3486 , ECP_0182 , ECs0176 , ECSE_0173 , Ent638_0712 , ESA_03168 , ispU (10) , SARI_02781 , SPAB_00284 , SSPA0220 , STY0244 , t0222 , uppS (20) , yaeS (8)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
cdsACDP-diglyceride synthase
ispBoctaprenyl diphosphate synthase 
yciBpredicted inner membrane protein 
nthDNA glycosylase and apyrimidinic (AP) lyase (endon 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: UDCPDPS

Undecaprenyl diphosphate synthase
frdp[c] + 8 ipdp[c] -> 8 ppi[c] + udcpdp[c]
Cofactor and Prosthetic Group Biosynthesis

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)