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Gene hscA from Escherichia coli str. K-12 substr. MG1655: DnaK-like molecular chaperone specific for IscU
Member of NCBI Protein Clusters PRK05183(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 944885
UniProtKB accession
RefSeq Protein accession NP_417021.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: hscA
  • locus tag: b2526
  • aliases: ECK2523, JW2510, hsc
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1U00
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG12130
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction chaperone protein HscA
Source References Functional description
GSDB
[PMID: 7665466]
[PMID: 9144776]
[PMID: 10869428]
Chaperone protein hscA (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0016226 : iron-sulfur cluster assembly : IGI
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0006457 : protein folding : IEA
  • MF: GO:0016887 : ATPase activity : IDA
  • BP: GO:0070417 : cellular response to cold : IEP
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0005524 : ATP binding : IDA
  • MF: GO:0043531 : ADP binding : IDA
  • BP: GO:0016226 : iron-sulfur cluster assembly : IEA
  • MF: GO:0016887 : ATPase activity : IEA
  • BP: GO:0016226 : iron-sulfur cluster assembly : IMP
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0051082 : unfolded protein binding : IEA
  • BP: GO:0006950 : response to stress : IEA
Domain Structure from CDD
  • hscA: chaperone protein HscA; Provisional
  • DMRL_synthase: 6,7-dimethyl-8-ribityllumazine synthase. riboflavin synthase subunit beta; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
hscA (64) , NT01EI_3179
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 gene neighbourhoods
phylogenetic profile
fdx[2Fe-2S] ferredoxin
 
 
dnaJchaperone Hsp40, co-chaperone with DnaK 
 
Phenotype Description Expression
Class
Reference(s)
Ampicillin sensitivity Knockout confers increased sensitivity to ampicillin Knock out
PMID: 20065048
Azetreonam sensitivity Knockout confers increased sensitivity to azetreonam Knock out
PMID: 20065048
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(not essential)
PMID: 20029369
(not essential)
Cefoxitin sensitivity Knockout confers increased sensitivity to cefoxitin Knock out
PMID: 20065048
Cephradine sensitivity Knockout confers increased sensitivity to cephradine Knock out
PMID: 20065048
Colistin sensitivity Knockout confers increased sensitivity to colistin Knock out
PMID: 20065048
Metronidazole sensitivity Knockout confers increased sensitivity to metronidazole Knock out
PMID: 20065048
Sulfamethoxazole sensitivity Knockout confers increased sensitivity to sulfamethoxazole Knock out
PMID: 20065048
Tetracycline sensitivity Knockout confers increased sensitivity to tetracycline Knock out
PMID: 20065048
Vancomycin sensitivity Knockout confers increased sensitivity to vancomycin Knock out
PMID: 20065048