COMBREX: ybaO in Escherichia coli str. K-12 substr. MG1655

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Gene ybaO from Escherichia coli str. K-12 substr. MG1655: predicted DNA-binding transcriptional regulator

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Summary

Member of NCBI Protein Clusters	CLSK879671(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID	945091
UniProtKB accession	P0ACJ5
RefSeq Protein accession	NP_414981.4 (PROVISIONAL)
Gene Symbol(s)	symbol: ybaO locus tag: b0447 aliases: ECK0441, JW0437, grp?
Organism	Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:	S Structure(s) available in PDB: C Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.) U Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium). Protein described in EcoCyc: G6247

Actions You Can Take

	Initiate the grant application process for experimentally validating this gene (info). Important notice about COMBREX grants
	Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
	Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
	Post a comment about this gene to appear on this page (info).

Function Predictions

Source	Predicted function(s)
NCBI Protein Cluster Prediction	Lrp/AsnC family transcriptional regulator

Experimental Validation

Source	References	Functional description
GSDB	Under Review	uncharacterized HTH-type transcriptional regulator ybaO (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)

Supporting Functional Information

Functional Status	Green (experimental evidence, uncurated)
GO terms	MF: GO:0016564 : transcription repressor activity : ISS CC: GO:0005622 : intracellular : IEA MF: GO:0016563 : transcription activator activity : ISS BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA BP: GO:0045449 : regulation of transcription : IEA MF: GO:0043565 : sequence-specific DNA binding : IEA BP: GO:0006350 : transcription : IEA MF: GO:0003677 : DNA binding : IEA MF: GO:0003700 : transcription factor activity : IEA BP: GO:0006350 : transcription : ISS
Domain Structure from CDD	WHTH_GntR: Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators. transcriptional regulator Hpr; Provisional Lrp: Transcriptional regulators [Transcription] See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	AsnC_trans_reg HTH_11 See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details)	[Download ] EcE24377A_0483 , ECH74115_0535 , EcHS_A0524 , EcolC_3168 , ECP_0508 , ECs0501 , ECSE_0473 , EcSMS35_0490 , SbBS512_E0370 , ybaO (14)