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Gene rpmA from Escherichia coli str. K-12 substr. MG1655: 50S ribosomal subunit protein L27
Member of NCBI Protein Clusters PRK05435(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945190
UniProtKB accession
RefSeq Protein accession NP_417652.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rpmA
  • locus tag: b3185
  • aliases: ECK3174, JW3152, rpz
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 50S ribosomal protein L27
Source References Functional description
[PMID: 1225626]
[PMID: 7556101]
[PMID: 10094780]
[PMID: 12809609]
[PMID: 16272117]
50S ribosomal protein L27 (source organism: Escherichia coli (strain K12).; strain specific ID: K12)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • CC: GO:0030529 : ribonucleoprotein complex : IEA
  • CC: GO:0005622 : intracellular : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0000049 : tRNA binding : IEA
  • MF: GO:0019843 : rRNA binding : IEA
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0003735 : structural constituent of ribosome : IEA
  • CC: GO:0005840 : ribosome : IEA
Domain Structure from CDD
  • Ribosomal_L27: Ribosomal L27 protein. 50S ribosomal protein L27; Validated

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
NT01EI_0450 , rpmA (125) , Tola_2378 , VCD_001170
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
rplU50S ribosomal subunit protein L21
yhbEconserved inner membrane protein
tsfprotein chain elongation factor EF-Ts 
lepAback-translocating Elongation Factor EF4, GTPase 
acpPacyl carrier protein (ACP) 
rluD23S rRNA pseudouridine synthase; specific to U1911 
rplI50S ribosomal subunit protein L9 
prfApeptide chain release factor RF-1 
rluApseudouridine synthase for 23S rRNA (position 746) 
rpmI50S ribosomal subunit protein L35 
frrribosome recycling factor 
truCtRNA U65 pseudouridine synthase 
rpsR30S ribosomal subunit protein S18 
rplQ50S ribosomal subunit protein L17 
rluC23S rRNA pseudouridine synthase; specific to U955, 
rpsP30S ribosomal subunit protein S16 
obgEGTPase involved in cell partioning and DNA repair 
pthpeptidyl-tRNA hydrolase 
tufBprotein chain elongation factor EF-Tu (duplicate o 
aspSaspartyl-tRNA synthetase 
rpsF30S ribosomal subunit protein S6 
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methylt 
yidCmembrane protein insertase 
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'- 
tufAprotein chain elongation factor EF-Tu (duplicate o 
ftsHprotease, ATP-dependent zinc-metallo 
rplS50S ribosomal subunit protein L19 
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N 
rpmG50S ribosomal subunit protein L33 
ssbsingle-stranded DNA-binding protein 
rncRNase III 
rplL50S ribosomal subunit protein L7/L12 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(not essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)