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Gene hscC from Escherichia coli str. K-12 substr. MG1655: Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription
Member of NCBI Protein Clusters CLSK879716(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945218
UniProtKB accession
RefSeq Protein accession NP_415183.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: hscC
  • locus tag: b0650
  • aliases: ECK0643, JW0645, ybeW
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: G6357
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Source Predicted function(s)
NCBI Protein Cluster Prediction Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription
Source References Functional description
GSDB Under Review chaperone protein hscC (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • MF: GO:0000166 : nucleotide binding : IEA
  • BP: GO:0006950 : response to stress : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0005515 : protein binding : IPI
Domain Structure from CDD
  • DnaK: Molecular chaperone [Posttranslational modification, protein turnover, chaperones]

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
EcolC_2995 , ECs0689 , hscC (13) , SC0687 , SeAg_B0702 , SeD_A0763 , SeHA_C0776 , SNSL254_A0716 , SPAB_02891 , SPC_0676 , ybeW (4)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
dnaJchaperone Hsp40, co-chaperone with DnaK