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Gene rsuA from Escherichia coli str. K-12 substr. MG1655: 16S rRNA U516 pseudouridine synthase
Member of NCBI Protein Clusters PRK10839(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945378
UniProtKB accession
RefSeq Protein accession NP_416688.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rsuA
  • locus tag: b2183
  • aliases: ECK2177, JW2171, yejD
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1KSK 1KSL 1KSV
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG12044
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 16S rRNA pseudouridylate synthase A
Source References Functional description
[PMID: 7612632]
[PMID: 10376875]
[PMID: 11953756]
Ribosomal small subunit pseudouridine synthase A (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • MF: GO:0016866 : intramolecular transferase activity : IEA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0009451 : RNA modification : IEA
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IMP
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IEA
  • BP: GO:0001522 : pseudouridine synthesis : IEA
  • BP: GO:0006364 : rRNA processing : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IDA
Domain Structure from CDD
  • PseudoU_synth_RsuA: PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacter.... (More)
  • PRK10839: 16S rRNA pseudouridylate synthase A; Provisional
  • S4: S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_00593 , EcolC_1464 , ECP_2224 , ECs3075 , ECSE_2452 , Ent638_2779 , ESA_01053 , rsuA (43) , rsuA1 , SARI_00665 , SPAB_00778 , SSPA0589 , yejD (4) , YPA_0984 , YPDSF_2428 , YPK_2793 , YPN_2710 , YPTS_1393
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
gene neighbourhoods
cpxRDNA-binding response regulator in two-component re
bcrbicyclomycin/multidrug efflux system 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
ftsItranspeptidase involved in septal peptidoglycan sy
ddlBD-alanine:D-alanine ligase
rpsA30S ribosomal subunit protein S1
kdpEDNA-binding response regulator in two-component re
cusRDNA-binding response regulator in two-component re
mrdAtranspeptidase involved in peptidoglycan synthesis
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de
mrdBcell wall shape-determining protein
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
qseBquorum sensing DNA-binding response regulator in t
phoBDNA-binding response regulator in two-component re
ompRDNA-binding response regulator in two-component re
baeRDNA-binding response regulator in two-component re
ftsWintegral membrane protein involved in stabilizing
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
ddlAD-alanine-D-alanine ligase A
recGATP-dependent DNA helicase
torRDNA-binding response regulator in two-component re
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent
yggWpredicted oxidoreductase, HemN family
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
yedWpredicted DNA-binding response regulator in two-co
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
priAPrimosome factor n' (replication factor Y)
murCUDP-N-acetylmuramate:L-alanine ligase
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
rimM16S rRNA processing protein
basRDNA-binding response regulator in two-component re
phoPDNA-binding response regulator in two-component re
arcADNA-binding response regulator in two-component re
mfdtranscription-repair coupling factor
creBDNA-binding response regulator in two-component re
coaDpantetheine-phosphate adenylyltransferase