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Gene dusC from Escherichia coli str. K-12 substr. MG1655: tRNA-dihydrouridine synthase C

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Summary
Member of NCBI Protein Clusters PRK10550(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945458
UniProtKB accession
RefSeq Protein accession NP_416645.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: dusC
  • locus tag: b2140
  • aliases: ECK2133, JW2128, yohI
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG12022

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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).

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Function Predictions
Source Predicted function(s)
NCBI Protein Cluster Prediction tRNA-dihydrouridine synthase C

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Experimental Validation
Source References Functional description
GSDB Under Review tRNA-dihydrouridine synthase C (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)

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Supporting Functional Information
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0008033 : tRNA processing : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0017150 : tRNA dihydrouridine synthase activity : IEA
  • MF: GO:0050660 : FAD binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0005515 : protein binding : IPI
Domain Structure from CDD
  • DUS_like_FMN: Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-dou.... (More)
  • Dus: Dihydrouridine synthase (Dus). Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_00655 , dusC (15) , ECA2799 , ECH74115_3266 , EcolC_1508 , ECP_2179 , ECs3026 , ECSE_2407 , Ent638_2742 , ESA_01098 , ETA_22500 , plu1512 , SARI_00724 , SeAg_B2320 , SeD_A2521 , SeHA_C2409 , SeSA_A2413 , SNSL254_A2364 , SPAB_00842 , Spro_1337 , SSPA0636 , y3015 , YE2886 , yohI (17) , YP_0963 , YPA_0885 , YpAngola_A1355 , YPDSF_2522 , YPK_2887 , YPN_2803 , YPO1175 , YpsIP31758_2808 , YPTB1216 , YPTS_1303