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Gene rluC from Escherichia coli str. K-12 substr. MG1655: 23S rRNA pseudouridine synthase; specific to U955, U2504, and U2580
Member of NCBI Protein Clusters PRK11025(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945637
UniProtKB accession
RefSeq Protein accession NP_415604.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rluC
  • locus tag: b1086
  • aliases: ECK1071, JW1072, yceC
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1V9K 1XPI
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG11118
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 23S rRNA pseudouridylate synthase C
Source References Functional description
[PMID: 9660827]
[PMID: 10089432]
Ribosomal large subunit pseudouridine synthase C (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IDA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0009451 : RNA modification : IEA
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IMP
  • BP: GO:0009451 : RNA modification : IMP
  • BP: GO:0016072 : rRNA metabolic process : IMP
  • BP: GO:0031118 : rRNA pseudouridine synthesis : IDA
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IEA
  • BP: GO:0001522 : pseudouridine synthesis : IEA
  • BP: GO:0006364 : rRNA processing : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IDA
Domain Structure from CDD
  • S4: N/A. hypothetical protein; Provisional
  • PRK11025: 23S rRNA pseudouridylate synthase C; Provisional
  • PseudoU_synth_RluCD_like: PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
APECO1_168 , CKO_01974 , EcolC_2515 , ECP_1078 , ECs1464 , ECSE_1149 , Ent638_1601 , ESA_02260 , NT01EI_2377 , rluA1 , rluC (32) , SARI_01811 , SeAg_B2001 , SeD_A2185 , SeHA_C1299 , SeSA_A1255 , SNSL254_A1284 , SPAB_02338 , Spro_1899 , SSPA1547 , yceC (8) , YPA_1934 , YPDSF_1855 , YPK_1678 , YPN_2037 , YPTS_2566
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
domain fusion
rpsP30S ribosomal subunit protein S16
pthpeptidyl-tRNA hydrolase
aspSaspartyl-tRNA synthetase
ftsHprotease, ATP-dependent zinc-metallo
yidCmembrane protein insertase
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-
rplS50S ribosomal subunit protein L19
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N
rplL50S ribosomal subunit protein L7/L12
rpmA50S ribosomal subunit protein L27
rncRNase III
aasfused 2-acylglycerophospho-ethanolamine acyl trans
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase
lepAback-translocating Elongation Factor EF4, GTPase
yihGinner membrane protein, Predicted acyltransferas
rplQ50S ribosomal subunit protein L17
ssbsingle-stranded DNA-binding protein
frrribosome recycling factor
prfApeptide chain release factor RF-1
yqcCconserved protein