Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene rluC from Escherichia coli str. K-12 substr. MG1655: 23S rRNA pseudouridine synthase; specific to U955, U2504, and U2580
Member of NCBI Protein Clusters PRK11025(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945637
UniProtKB accession
RefSeq Protein accession NP_415604.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rluC
  • locus tag: b1086
  • aliases: ECK1071, JW1072, yceC
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1V9K 1XPI
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG11118
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 23S rRNA pseudouridylate synthase C
Source References Functional description
GSDB
[PMID: 9660827]
[PMID: 10089432]
Ribosomal large subunit pseudouridine synthase C (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number 4.2.1.70 (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IDA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0009451 : RNA modification : IEA
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IMP
  • BP: GO:0009451 : RNA modification : IMP
  • BP: GO:0016072 : rRNA metabolic process : IMP
  • BP: GO:0031118 : rRNA pseudouridine synthesis : IDA
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IEA
  • BP: GO:0001522 : pseudouridine synthesis : IEA
  • BP: GO:0006364 : rRNA processing : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IDA
Domain Structure from CDD
  • S4: N/A. hypothetical protein; Provisional
  • PRK11025: 23S rRNA pseudouridylate synthase C; Provisional
  • PseudoU_synth_RluCD_like: PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
APECO1_168 , CKO_01974 , EcolC_2515 , ECP_1078 , ECs1464 , ECSE_1149 , Ent638_1601 , ESA_02260 , NT01EI_2377 , rluA1 , rluC (32) , SARI_01811 , SeAg_B2001 , SeD_A2185 , SeHA_C1299 , SeSA_A1255 , SNSL254_A1284 , SPAB_02338 , Spro_1899 , SSPA1547 , yceC (8) , YPA_1934 , YPDSF_1855 , YPK_1678 , YPN_2037 , YPTS_2566
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
domain fusion
rpsP30S ribosomal subunit protein S16
 
 
pthpeptidyl-tRNA hydrolase
 
 
aspSaspartyl-tRNA synthetase
 
 
ftsHprotease, ATP-dependent zinc-metallo
 
 
yidCmembrane protein insertase
 
 
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-
 
 
rplS50S ribosomal subunit protein L19
 
 
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N
 
 
rplL50S ribosomal subunit protein L7/L12
 
 
rpmA50S ribosomal subunit protein L27
 
 
rncRNase III
 
 
aasfused 2-acylglycerophospho-ethanolamine acyl trans
 
 
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase
 
 
lepAback-translocating Elongation Factor EF4, GTPase
 
 
yihGinner membrane protein, Predicted acyltransferas
 
 
rplQ50S ribosomal subunit protein L17
 
 
ssbsingle-stranded DNA-binding protein
 
 
frrribosome recycling factor
 
 
prfApeptide chain release factor RF-1
 
 
yqcCconserved protein