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Gene pth from Escherichia coli str. K-12 substr. MG1655: peptidyl-tRNA hydrolase
Member of NCBI Protein Clusters PRK05426(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945765
UniProtKB accession
RefSeq Protein accession NP_415722.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: pth
  • locus tag: b1204
  • aliases: ECK1192, JW1195, asuA?, rap
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 2PTH
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10785
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction peptidyl-tRNA hydrolase
Source References Functional description
[PMID: 1833189]
[PMID: 9144799]
[PMID: 9303320]
Peptidyl-tRNA hydrolase (source organism: Escherichia coli (strain K12).; strain specific ID: K12)
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • MF: GO:0004045 : aminoacyl-tRNA hydrolase activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • PTH: Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA wh.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_01259 , EcolC_2422 , ECP_1252 , ECs1709 , ECSE_1254 , Ent638_2344 , ESA_01489 , pth (38) , SARI_01169 , SPAB_01443 , Spro_1984 , SSPA1017
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
ychFpredicted GTP-binding protein
rplS50S ribosomal subunit protein L19 
rluApseudouridine synthase for 23S rRNA (position 746) 
rpmI50S ribosomal subunit protein L35 
frrribosome recycling factor 
truCtRNA U65 pseudouridine synthase 
rpsR30S ribosomal subunit protein S18 
rluC23S rRNA pseudouridine synthase; specific to U955, 
obgEGTPase involved in cell partioning and DNA repair 
rplL50S ribosomal subunit protein L7/L12 
rpsF30S ribosomal subunit protein S6 
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methylt 
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N 
rpmG50S ribosomal subunit protein L33 
ftsHprotease, ATP-dependent zinc-metallo 
rpsP30S ribosomal subunit protein S16 
aspSaspartyl-tRNA synthetase 
ssbsingle-stranded DNA-binding protein 
rncRNase III 
rplQ50S ribosomal subunit protein L17 
rpmA50S ribosomal subunit protein L27 
tsfprotein chain elongation factor EF-Ts 
lepAback-translocating Elongation Factor EF4, GTPase 
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'- 
acpPacyl carrier protein (ACP) 
rluD23S rRNA pseudouridine synthase; specific to U1911 
yidCmembrane protein insertase 
tufAprotein chain elongation factor EF-Tu (duplicate o 
tufBprotein chain elongation factor EF-Tu (duplicate o 
rplI50S ribosomal subunit protein L9 
prfApeptide chain release factor RF-1 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)