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Gene rluB from Escherichia coli str. K-12 substr. MG1655: 23S rRNA pseudouridylate synthase
Member of NCBI Protein Clusters PRK10700(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945840
UniProtKB accession
RefSeq Protein accession NP_415785.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rluB
  • locus tag: b1269
  • aliases: ECK1263, JW1261, yciL
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG12433
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 23S rRNA pseudouridylate synthase B
Source References Functional description
GSDB Under Review ribosomal large subunit pseudouridine synthase B (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • MF: GO:0016866 : intramolecular transferase activity : IEA
  • BP: GO:0009451 : RNA modification : IEA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IMP
  • MF: GO:0009982 : pseudouridine synthase activity : IMP
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IEA
  • BP: GO:0001522 : pseudouridine synthesis : IEA
  • BP: GO:0006364 : rRNA processing : IEA
Domain Structure from CDD
  • PRK10700: 23S rRNA pseudouridylate synthase B; Provisional
  • PseudoU_synth_RluB: PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryo.... (More)
  • S4: S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_01343 , EcolC_2359 , ECP_1316 , ECs1841 , ECSE_1317 , Ent638_2201 , NT01EI_1702 , rluB (23) , SARI_01241 , SPAB_01525 , Spro_2662 , SSPA1076 , STY1331 , yciL (16)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
qseBquorum sensing DNA-binding response regulator in t
rpsA30S ribosomal subunit protein S1
kdpEDNA-binding response regulator in two-component re
mrdAtranspeptidase involved in peptidoglycan synthesis
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de
phoBDNA-binding response regulator in two-component re
ompRDNA-binding response regulator in two-component re
recGATP-dependent DNA helicase
torRDNA-binding response regulator in two-component re
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent
yedWpredicted DNA-binding response regulator in two-co
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
priAPrimosome factor n' (replication factor Y)
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
ddlBD-alanine:D-alanine ligase
murCUDP-N-acetylmuramate:L-alanine ligase
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
rimM16S rRNA processing protein
phoPDNA-binding response regulator in two-component re
arcADNA-binding response regulator in two-component re
creBDNA-binding response regulator in two-component re
coaDpantetheine-phosphate adenylyltransferase
cpxRDNA-binding response regulator in two-component re
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
ddlAD-alanine-D-alanine ligase A
mrdBcell wall shape-determining protein
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
basRDNA-binding response regulator in two-component re
yggWpredicted oxidoreductase, HemN family
baeRDNA-binding response regulator in two-component re
ftsWintegral membrane protein involved in stabilizing
cusRDNA-binding response regulator in two-component re
ftsItranspeptidase involved in septal peptidoglycan sy
mfdtranscription-repair coupling factor