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Gene ruvC from Escherichia coli str. K-12 substr. MG1655: component of RuvABC resolvasome, endonuclease
Member of NCBI Protein Clusters PRK00039(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 946378
UniProtKB accession
RefSeq Protein accession NP_416377.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ruvC
  • locus tag: b1863
  • aliases: ECK1864, JW1852
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1HJR
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10925
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Source Predicted function(s)
NCBI Protein Cluster Prediction Holliday junction resolvase
Source References Functional description
[PMID: 1661673]
[PMID: 1758493]
[PMID: 7923356]
Crossover junction endodeoxyribonuclease ruvC (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • MF: GO:0046872 : metal ion binding : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • BP: GO:0006310 : DNA recombination : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • MF: GO:0003676 : nucleic acid binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0004520 : endodeoxyribonuclease activity : IEA
  • MF: GO:0004518 : nuclease activity : IEA
  • MF: GO:0008821 : crossover junction endodeoxyribonuclease activity : IEA
  • MF: GO:0000287 : magnesium ion binding : IEA
  • BP: GO:0006974 : response to DNA damage stimulus : IEA
Domain Structure from CDD
  • RuvC_resolvase: Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates duri.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
NT01EI_1597 , ruvC (69)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
yebCconserved protein, UPF0082 family
lpxPpalmitoleoyl-acyl carrier protein (ACP)-dependent  
lpxLlauryl-acyl carrier protein (ACP)-dependent acyltr 
lntapolipoprotein N-acyltransferase 
lpxMmyristoyl-acyl carrier protein (ACP)-dependent acy 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(not essential)
PMID: 20029369
(not essential)
Ciprofloxacin sensitivity Knockout confers increased sensitivity to ciprofloxacin Knock out
PMID: 20065048