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Gene aroC from Escherichia coli str. K-12 substr. MG1655: chorismate synthase
Member of NCBI Protein Clusters PRK05382(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 946814
UniProtKB accession
RefSeq Protein accession NP_416832.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: aroC
  • locus tag: b2329
  • aliases: ECK2323, JW2326
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10075
This gene is already gold standard. If you believe there is an additional, validatable function not described here, please contact us.
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
This gene is already gold standard. If you believe there is an additional, validatable function not described here, please contact us.
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction chorismate synthase
Source References Functional description
GSDB
[PMID: 2969724]
Chorismate synthase (source organism: Escherichia coli (strain K12).; strain specific ID: K12 AB2849/pGM602) / Curator Brian Anton (record returned: Sep 20 2010)
Functional Status greenGold (experimental evidence, curated)
EC number
GO terms
  • BP: GO:0009073 : aromatic amino acid family biosynthetic process : IEA
  • MF: GO:0004107 : chorismate synthase activity : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
Domain Structure from CDD
  • Chorismate_synthase: Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway. Chorismate synthase (CS; 5-enolpyruv.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
aroC (52) , CKO_00456 , EcolC_1323 , ECP_2368 , ECs3213 , ECSE_2638 , Ent638_2877 , ESA_00886 , NT01EI_2754 , PBPRA2714 , SARI_00516 , SG1627 , SPAB_00586 , Spro_3374 , SSPA0444 , YPA_2092 , YPDSF_2009 , YPK_1514 , YPN_2195 , YPTS_2727
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 gene neighbourhoods
phylogenetic profile
prmBN5-glutamine methyltransferase
 
 
ydiBquinate/shikimate 5-dehydrogenase, NAD(P)-binding 
 
aroA5-enolpyruvylshikimate-3-phosphate synthetase 
 
aroEdehydroshikimate reductase, NAD(P)-binding 
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: CHORS

Name
chorismate synthase
Formula
3psme[c] -> chor[c] + pi[c]
Pathway
Tyrosine, Tryptophan, and Phenylalanine Metabolism

Source: Ported to COMBREX by Segre's Lab
KEGG