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Gene rnc from Escherichia coli str. K-12 substr. MG1655: RNase III
Member of NCBI Protein Clusters PRK00102(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947033
UniProtKB accession
RefSeq Protein accession NP_417062.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rnc
  • locus tag: b2567
  • aliases: ECK2565, JW2551, ranA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10857
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction ribonuclease III
COMBREX rnc ribonuclease 3 (source organism: Salmonella paratyphi; strain specific ID: NCBI_TaxID=54388) [More information on this prediction]
Source References Functional description
GSDB Under Review Ribonuclease 3 (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • BP: GO:0016075 : rRNA catabolic process : IEA
  • BP: GO:0006397 : mRNA processing : IEA
  • CC: GO:0005622 : intracellular : IEA
  • MF: GO:0003725 : double-stranded RNA binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0004518 : nuclease activity : IEA
  • BP: GO:0006364 : rRNA processing : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0004525 : ribonuclease III activity : IEA
  • MF: GO:0004519 : endonuclease activity : IEA
  • BP: GO:0006396 : RNA processing : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • DSRM: Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Foun.... (More)
  • rnc: ribonuclease III; Reviewed
  • RIBOc: RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RN.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
NT01EI_3032 , rnc (61) , rncS (2)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
lepBleader peptidase (signal peptidase I)
eramembrane-associated, 16S rRNA-binding GTPase
tsfprotein chain elongation factor EF-Ts 
lepAback-translocating Elongation Factor EF4, GTPase 
acpPacyl carrier protein (ACP) 
rluD23S rRNA pseudouridine synthase; specific to U1911 
rplI50S ribosomal subunit protein L9 
prfApeptide chain release factor RF-1 
rluApseudouridine synthase for 23S rRNA (position 746) 
rpmI50S ribosomal subunit protein L35 
frrribosome recycling factor 
rpsP30S ribosomal subunit protein S16 
truCtRNA U65 pseudouridine synthase 
pthpeptidyl-tRNA hydrolase 
rpsR30S ribosomal subunit protein S18 
tufBprotein chain elongation factor EF-Tu (duplicate o 
aspSaspartyl-tRNA synthetase 
rluC23S rRNA pseudouridine synthase; specific to U955, 
obgEGTPase involved in cell partioning and DNA repair 
yidCmembrane protein insertase 
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'- 
tufAprotein chain elongation factor EF-Tu (duplicate o 
rpsF30S ribosomal subunit protein S6 
rplS50S ribosomal subunit protein L19 
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methylt 
ftsHprotease, ATP-dependent zinc-metallo 
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N 
rpmG50S ribosomal subunit protein L33 
ssbsingle-stranded DNA-binding protein 
rplQ50S ribosomal subunit protein L17 
rplL50S ribosomal subunit protein L7/L12 
rpmA50S ribosomal subunit protein L27 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(not essential)
PMID: 20029369
(candidate essential)