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Gene rluD from Escherichia coli str. K-12 substr. MG1655: 23S rRNA pseudouridine synthase; specific to U1911, U1915, and U1917
Member of NCBI Protein Clusters PRK11180(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947087
UniProtKB accession
RefSeq Protein accession NP_417085.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rluD
  • locus tag: b2594
  • aliases: ECK2592, JW2576, sfhB, yfiI
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction 23S rRNA pseudouridine synthase D
Source References Functional description
[PMID: 9814761]
[PMID: 11087118]
[PMID: 11453071]
Ribosomal large subunit pseudouridine synthase D (source organism: Escherichia coli (strain K12).; strain specific ID: K12 / MG1655 / ATCC 47076)
Functional Status greenGreen (experimental evidence, uncurated)
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • BP: GO:0000027 : ribosomal large subunit assembly : IMP
  • BP: GO:0009451 : RNA modification : IEA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IMP
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IEA
  • BP: GO:0001522 : pseudouridine synthesis : IEA
  • BP: GO:0006364 : rRNA processing : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IDA
Domain Structure from CDD
  • rluD: 23S rRNA pseudouridine synthase D; Provisional
  • PseudoU_synth_RluCD_like: PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and .... (More)
  • S4: S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
rluD (67) , sfhB
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
domain fusion
yfiHconserved protein, UPF0124 family
rplL50S ribosomal subunit protein L7/L12 
rpmA50S ribosomal subunit protein L27 
rncRNase III 
ftsHprotease, ATP-dependent zinc-metallo 
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase 
rplQ50S ribosomal subunit protein L17 
ssbsingle-stranded DNA-binding protein 
frrribosome recycling factor 
aasfused 2-acylglycerophospho-ethanolamine acyl trans 
lepAback-translocating Elongation Factor EF4, GTPase 
yihGinner membrane protein, Predicted acyltransferas 
rpsP30S ribosomal subunit protein S16 
pthpeptidyl-tRNA hydrolase 
aspSaspartyl-tRNA synthetase 
prfApeptide chain release factor RF-1 
yidCmembrane protein insertase 
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'- 
rplS50S ribosomal subunit protein L19 
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N 
yqcCconserved protein  
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(not essential)
PMID: 20029369
(not essential)