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Gene rplS from Escherichia coli str. K-12 substr. MG1655: 50S ribosomal subunit protein L19
Member of NCBI Protein Clusters PRK05338(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947096
UniProtKB accession
RefSeq Protein accession NP_417097.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rplS
  • locus tag: b2606
  • aliases: ECK2603, JW2587
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 50S ribosomal protein L19
Source References Functional description
[PMID: 339951]
[PMID: 10094780]
[PMID: 12809609]
[PMID: 16272117]
50S ribosomal protein L19 (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • CC: GO:0030529 : ribonucleoprotein complex : IEA
  • CC: GO:0005622 : intracellular : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0019843 : rRNA binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0003735 : structural constituent of ribosome : IEA
  • CC: GO:0005840 : ribosome : IEA
Domain Structure from CDD
  • Ribosomal_L19: Ribosomal protein L19. 50S ribosomal protein L19; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
KP1_4184 , NT01EI_3220 , rplS (92) , VCD_001042
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
gene neighbourhoods
rpsP30S ribosomal subunit protein S16
trmDtRNA m(1)G37 methyltransferase, SAM-dependent 
rplI50S ribosomal subunit protein L9
pthpeptidyl-tRNA hydrolase
tufBprotein chain elongation factor EF-Tu (duplicate o
aspSaspartyl-tRNA synthetase
prfApeptide chain release factor RF-1
yidCmembrane protein insertase
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-
tufAprotein chain elongation factor EF-Tu (duplicate o
rluApseudouridine synthase for 23S rRNA (position 746)
rpmI50S ribosomal subunit protein L35
frrribosome recycling factor
truCtRNA U65 pseudouridine synthase
rpsR30S ribosomal subunit protein S18
rluC23S rRNA pseudouridine synthase; specific to U955,
obgEGTPase involved in cell partioning and DNA repair
rplL50S ribosomal subunit protein L7/L12
rpsF30S ribosomal subunit protein S6
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methylt
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N
rpmG50S ribosomal subunit protein L33
ftsHprotease, ATP-dependent zinc-metallo
rplQ50S ribosomal subunit protein L17
ssbsingle-stranded DNA-binding protein
rncRNase III
rpmA50S ribosomal subunit protein L27
tsfprotein chain elongation factor EF-Ts
lepAback-translocating Elongation Factor EF4, GTPase
acpPacyl carrier protein (ACP)
rluD23S rRNA pseudouridine synthase; specific to U1911
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)