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Gene grpE from Escherichia coli str. K-12 substr. MG1655: heat shock protein
Member of NCBI Protein Clusters PRK10325(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947097
UniProtKB accession
RefSeq Protein accession NP_417104.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: grpE
  • locus tag: b2614
  • aliases: ECK2610, JW2594
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1DKG
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10416
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction heat shock protein GrpE
Source References Functional description
[PMID: 8890154]
[PMID: 12885238]
[PMID: 15136046]
[PMID: 9103205]
Protein grpE (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • MF: GO:0051087 : chaperone binding : IEA
  • MF: GO:0005515 : protein binding : IEA
  • CC: GO:0005737 : cytoplasm : IDA
  • BP: GO:0006457 : protein folding : IEA
  • MF: GO:0000774 : adenyl-nucleotide exchange factor activity : IEA
  • MF: GO:0042803 : protein homodimerization activity : IEA
  • BP: GO:0006950 : response to stress : IEA
  • BP: GO:0009408 : response to heat : IEP
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0030150 : protein import into mitochondrial matrix : IEA
  • CC: GO:0005739 : mitochondrion : IEA
Domain Structure from CDD
  • GrpE: Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]
  • GrpE: GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain o.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
EcolC_1070 , ECP_2614 , ECs3476 , ECSE_2897 , Ent638_3094 , ESA_00642 , grpE (35) , SSPA2365
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
repDNA helicase and single-stranded DNA-dependent ATP
helDDNA helicase IV
uvrDDNA-dependent ATPase I and helicase II
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)