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Gene nth from Escherichia coli str. K-12 substr. MG1655: DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III)
Member of NCBI Protein Clusters PRK10702(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947122
UniProtKB accession
RefSeq Protein accession NP_416150.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: nth
  • locus tag: b1633
  • aliases: ECK1629, JW1625
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 2ABK
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10662
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Source Predicted function(s)
NCBI Protein Cluster Prediction endonuclease III
Source References Functional description
GSDB Under Review endonuclease III (source organism: Escherichia coli; strain specific ID: NCBI_TaxID=562)
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • CC: GO:0005622 : intracellular : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • MF: GO:0003906 : DNA-(apurinic or apyrimidinic site) lyase activity : IEA
  • BP: GO:0006284 : base-excision repair : IEA
  • MF: GO:0051536 : iron-sulfur cluster binding : IEA
  • MF: GO:0005506 : iron ion binding : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • BP: GO:0006974 : response to DNA damage stimulus : IEA
  • MF: GO:0004519 : endonuclease activity : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • MF: GO:0051539 : 4 iron, 4 sulfur cluster binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0016798 : hydrolase activity, acting on glycosyl bonds : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0046872 : metal ion binding : IEA
Domain Structure from CDD
  • ENDO3c: endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alk.... (More)
  • FES: FES domain. iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
  • PRK10702: endonuclease III; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
APP7_0945 , Asuc_1741 , CGSHiGG_02185 , CKO_01645 , EcolC_1996 , ECP_1578 , ECs2342 , ECSE_1755 , Ent638_1815 , ESA_01992 , HSM_1549 , modC , nth (62) , Patl_2971 , PBPRA2566 , SARI_01529 , Sden_1869 , SG1449 , Shal_1925 , SPAB_01867 , Spea_2359 , SSPA1300 , Tola_1443 , VC1011 , VCD_003327 , VIBHAR_02970 , VP2108 , VS_0971 , VV1186 , VV1_3099 , YPA_1598 , YPDSF_0896 , YPK_2013 , YPN_1707 , YPTS_2230
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
rsxEelectron transport complex inner membrane NADH-qui
ispBoctaprenyl diphosphate synthase 
yciBpredicted inner membrane protein 
ispUundecaprenyl pyrophosphate synthase