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Gene dusB from Escherichia coli str. K-12 substr. MG1655: tRNA-dihydrouridine synthase B
Member of NCBI Protein Clusters PRK10415(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947707
UniProtKB accession
RefSeq Protein accession NP_417726.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: dusB
  • locus tag: b3260
  • aliases: ECK3247, JW3228, yhdG
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG11311
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction tRNA-dihydrouridine synthase B
Source References Functional description
GSDB Under Review tRNA-dihydrouridine synthase B (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0008033 : tRNA processing : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0017150 : tRNA dihydrouridine synthase activity : IEA
  • MF: GO:0050660 : FAD binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0005515 : protein binding : IPI
Domain Structure from CDD
  • DUS_like_FMN: Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-dou.... (More)
  • nifR3_yhdG: putative TIM-barrel protein, nifR3 family. Members of this family show a distant relationship to alpha/beta (TIM) barrel.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_04672 , dusB (24) , ECA0256 , EcolC_0446 , ECP_3353 , ECs4132 , ECSE_3541 , Ent638_3699 , ESA_03650 , NT01EI_3505 , plu4088 , SARI_04246 , SPAB_04218 , Spro_4423 , SSPA3037 , YE3816 , yhdG (17) , YPA_3667 , YPDSF_0261 , YPK_0453 , YPN_3517 , YPO3655 , YpsIP31758_0386 , YPTB3576 , YPTS_3764
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
fisglobal DNA-binding transcriptional dual regulator
Phenotype Description Expression
Enoxacin sensitivity Knockout confers increased sensitivity to enoxacin Knock out
PMID: 20065048
Nitrofurantoin sensitivity Knockout confers increased sensitivity to nitrofurantoin Knock out
PMID: 20065048
Triclosan sensitivity Knockout confers increased sensitivity to triclosan Knock out
PMID: 20065048