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Gene trxA from Escherichia coli str. K-12 substr. MG1655: thioredoxin 1
Member of NCBI Protein Clusters PRK09381(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948289
UniProtKB accession
RefSeq Protein accession NP_418228.2 (PROVISIONAL)
Gene Symbol(s)
  • symbol: trxA
  • locus tag: b3781
  • aliases: ECK3773, JW5856, dasC, fipA, tsnC
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction thioredoxin
Source References Functional description
GSDB Under Review thioredoxin-1 (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0044419 : interspecies interaction between organisms : IEA
  • MF: GO:0015035 : protein disulfide oxidoreductase activity : IEA
  • BP: GO:0022900 : electron transport chain : IEA
  • BP: GO:0006662 : glycerol ether metabolic process : IEA
  • BP: GO:0006810 : transport : IEA
  • BP: GO:0045454 : cell redox homeostasis : IEA
  • MF: GO:0009055 : electron carrier activity : IEA
Domain Structure from CDD
  • TRX_family: TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II,.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_00123 , ECA4212 , fipA (2) , NT01EI_0088 , SG2387 , Spro_0159 , Tola_2659 , trx (3) , trxA (52) , trxA2 , VIBHAR_00337 , YPA_0150 , YPDSF_3486 , YPK_4035 , YPN_0095 , YPTS_0178
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 domain fusion
gltDglutamate synthase, 4Fe-4S protein, small subunit
trxBthioredoxin reductase, FAD/NAD(P)-binding
dnaJchaperone Hsp40, co-chaperone with DnaK
ahpFalkyl hydroperoxide reductase, F52a subunit, FAD/N
Phenotype Description Expression
Rifampicin sensitivity Knockout confers increased sensitivity to rifampicin Knock out
PMID: 20065048