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Gene hemY from Escherichia coli str. K-12 substr. MG1655: predicted protoheme IX synthesis protein
Member of NCBI Protein Clusters PRK10747(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948311
UniProtKB accession
RefSeq Protein accession NP_418246.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: hemY
  • locus tag: b3802
  • aliases: ECK3796, JW3774
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10434
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Source Predicted function(s)
NCBI Protein Cluster Prediction putative protoheme IX biogenesis protein
Source References Functional description
GSDB Under Review protein hemY (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0006779 : porphyrin biosynthetic process : IEA
  • BP: GO:0042168 : heme metabolic process : IEA
  • MF: GO:0005488 : binding : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • CC: GO:0016021 : integral to membrane : IEA
Domain Structure from CDD
  • PRK10747: putative protoheme IX biogenesis protein; Provisional
  • HemY_N: HemY protein N-terminus. This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_00144 , EcolC_4205 , ECP_3994 , ECs4732 , ECSE_4083 , Ent638_3990 , hemY (40) , KP1_0160 , SARI_03717 , SPAB_04883 , SSPA3515
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
hemXpredicted uroporphyrinogen III methylase
fisglobal DNA-binding transcriptional dual regulator 
lolBOM lipoprotein required for localization of lipopr 
rdgCnucleoid-associated ssDNA and dsDNA binding protei 
ppdDpredicted major pilin subunit 
lptClipopolysaccharide export, IM-tethered periplasmic 
xerCsite-specific tyrosine recombinase 
yggXprotein that protects iron-sulfur proteins against 
ftsNessential cell division protein 
yrbApredicted DNA-binding transcriptional regulator, B 
lptELPS assembly OM complex LptDE, lipoprotein compone 
yjgAconserved protein, ribosome-associated 
sspBClpXP protease specificity-enhancing factor 
ybeXpredicteed ion transport