Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
Genes with solved structures in PDB
Genes with Pfam domains shared with human proteins
Genes with products purified by PSI
Genes cloned by PSI
close options


Gene rplL from Escherichia coli str. K-12 substr. MG1655: 50S ribosomal subunit protein L7/L12
Member of NCBI Protein Clusters PRK00157(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948489
UniProtKB accession
RefSeq Protein accession NP_418413.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rplL
  • locus tag: b3986
  • aliases: ECK3977, JW3949
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 50S ribosomal protein L7/L12
Source References Functional description
[PMID: 4573678]
[PMID: 773698]
[PMID: 9298646]
[PMID: 9868784]
[PMID: 9600841]
[PMID: 10094780]
[PMID: 3309338]
[PMID: 8603708]
[PMID: 9515737]
50S ribosomal protein L7/L12 (source organism: Escherichia coli (strain K12).; strain specific ID: MRE-600)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • CC: GO:0022625 : cytosolic large ribosomal subunit : IDA
  • MF: GO:0003735 : structural constituent of ribosome : IDA
  • CC: GO:0005622 : intracellular : IEA
  • CC: GO:0030529 : ribonucleoprotein complex : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003735 : structural constituent of ribosome : IEA
  • CC: GO:0005840 : ribosome : IEA
Domain Structure from CDD
  • Ribosomal_L7_L12: Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
rplL (63) , VCD_001297
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
rplJ50S ribosomal subunit protein L10
tsfprotein chain elongation factor EF-Ts 
lepAback-translocating Elongation Factor EF4, GTPase 
acpPacyl carrier protein (ACP) 
rluD23S rRNA pseudouridine synthase; specific to U1911 
rpsP30S ribosomal subunit protein S16 
rplI50S ribosomal subunit protein L9 
pthpeptidyl-tRNA hydrolase 
tufBprotein chain elongation factor EF-Tu (duplicate o 
aspSaspartyl-tRNA synthetase 
prfApeptide chain release factor RF-1 
yidCmembrane protein insertase 
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'- 
tufAprotein chain elongation factor EF-Tu (duplicate o 
rplS50S ribosomal subunit protein L19 
rluApseudouridine synthase for 23S rRNA (position 746) 
rpmI50S ribosomal subunit protein L35 
frrribosome recycling factor 
truCtRNA U65 pseudouridine synthase 
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N 
rpsR30S ribosomal subunit protein S18 
rpmG50S ribosomal subunit protein L33 
rluC23S rRNA pseudouridine synthase; specific to U955, 
obgEGTPase involved in cell partioning and DNA repair 
rpsF30S ribosomal subunit protein S6 
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methylt 
rplQ50S ribosomal subunit protein L17 
ftsHprotease, ATP-dependent zinc-metallo 
ssbsingle-stranded DNA-binding protein 
rncRNase III 
rpmA50S ribosomal subunit protein L27 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)