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Gene rluF from Escherichia coli str. K-12 substr. MG1655: 23S rRNA U2604 pseudouridine synthase
Member of NCBI Protein Clusters PRK10475(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948519
UniProtKB accession
RefSeq Protein accession NP_418446.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rluF
  • locus tag: b4022
  • aliases: ECK4014, JW3982, yjbC
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 2GML 3DH3
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG11921
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 23S rRNA pseudouridine synthase F
Source References Functional description
GSDB Under Review ribosomal large subunit pseudouridine synthase F (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • MF: GO:0016866 : intramolecular transferase activity : IEA
  • BP: GO:0009451 : RNA modification : IEA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0000455 : enzyme-directed rRNA pseudouridine synthesis : IMP
  • MF: GO:0009982 : pseudouridine synthase activity : IMP
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0009982 : pseudouridine synthase activity : IEA
  • BP: GO:0001522 : pseudouridine synthesis : IEA
  • BP: GO:0006364 : rRNA processing : IEA
Domain Structure from CDD
  • PseudoU_synth_RluF: PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial protei.... (More)
  • PRK10475: 23S rRNA pseudouridine synthase F; Provisional
  • S4: S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03898 , EcolC_4008 , ECP_4240 , ECs5005 , ECSE_4307 , Ent638_0226 , rluF (9) , SARI_03464 , SeAg_B4444 , SeD_A4604 , SeHA_C4528 , SeSA_A4405 , SNSL254_A4530 , SPAB_05187 , SSPA3740 , yjbC (27) , YPK_3069 , YPTB1058 , YPTS_1109
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
mrdBcell wall shape-determining protein
qseBquorum sensing DNA-binding response regulator in t
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
coaDpantetheine-phosphate adenylyltransferase
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
rpsA30S ribosomal subunit protein S1
kdpEDNA-binding response regulator in two-component re
baeRDNA-binding response regulator in two-component re
ftsWintegral membrane protein involved in stabilizing
ddlAD-alanine-D-alanine ligase A
yggWpredicted oxidoreductase, HemN family
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
mrdAtranspeptidase involved in peptidoglycan synthesis
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de
murCUDP-N-acetylmuramate:L-alanine ligase
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
phoBDNA-binding response regulator in two-component re
ompRDNA-binding response regulator in two-component re
basRDNA-binding response regulator in two-component re
phoPDNA-binding response regulator in two-component re
mfdtranscription-repair coupling factor
recGATP-dependent DNA helicase
torRDNA-binding response regulator in two-component re
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
creBDNA-binding response regulator in two-component re
ftsItranspeptidase involved in septal peptidoglycan sy
priAPrimosome factor n' (replication factor Y)
ddlBD-alanine:D-alanine ligase
arcADNA-binding response regulator in two-component re
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent
cpxRDNA-binding response regulator in two-component re
cusRDNA-binding response regulator in two-component re
yedWpredicted DNA-binding response regulator in two-co
rimM16S rRNA processing protein