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Gene malF from Escherichia coli str. K-12 substr. MG1655: maltose transporter subunit
Member of NCBI Protein Clusters PRK10999(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948532
UniProtKB accession
RefSeq Protein accession NP_418457.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: malF
  • locus tag: b4033
  • aliases: ECK4025, JW3993, malJ
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction maltose transporter membrane protein
Source References Functional description
[PMID: 16453726]
[PMID: 2170984]
[PMID: 1915262]
[PMID: 9214624]
[PMID: 9401026]
[PMID: 8636026]
[PMID: 10809785]
[PMID: 15919996]
Maltose transport system permease protein malF (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0015768 : maltose transport : IDA
  • BP: GO:0008643 : carbohydrate transport : IEA
  • MF: GO:0015609 : maltooligosaccharide-importing ATPase activity : IGI
  • BP: GO:0006810 : transport : IEA
  • BP: GO:0042956 : maltodextrin transport : IGI
  • CC: GO:0005886 : plasma membrane : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • MF: GO:0015423 : maltose-transporting ATPase activity : IDA
  • CC: GO:0043190 : ATP-binding cassette (ABC) transporter complex : IDA
  • CC: GO:0016020 : membrane : IEA
  • MF: GO:0005215 : transporter activity : IEA
Domain Structure from CDD
  • TM_PBP2: Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters .... (More)
  • malF: maltose transporter membrane protein; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
malF (48)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
malGmaltose transporter subunit
malEmaltose transporter subunit
ycjNpredicted sugar transporter subunit: periplasmic-b 
ugpEglycerol-3-phosphate transporter subunit 
ycjPpredicted sugar transporter subunit: membrane comp 
ugpBglycerol-3-phosphate transporter subunit 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: MALTHXabc

maltohexaose transport via ABC system
atp[c] + h2o[c] + malthx[e] -> adp[c] + h[c] + malthx[c] + pi[c]
Transport, Extracellular
Other Genes

Metabolic Reaction: MALTPTabc

maltopentaose transport via ABC system
atp[c] + h2o[c] + maltpt[e] -> adp[c] + h[c] + maltpt[c] + pi[c]
Transport, Extracellular
Other Genes

Metabolic Reaction: MALTTRabc

Maltotriose transport via ABC system
atp[c] + h2o[c] + malttr[e] -> adp[c] + h[c] + malttr[c] + pi[c]
Transport, Extracellular
Other Genes

Metabolic Reaction: MALTTTRabc

maltotetraose transport via ABC system
atp[c] + h2o[c] + maltttr[e] -> adp[c] + h[c] + maltttr[c] + pi[c]
Transport, Extracellular
Other Genes

Metabolic Reaction: MALTabc

maltose transport via ABC system
atp[c] + h2o[c] + malt[e] -> adp[c] + h[c] + malt[c] + pi[c]
Transport, Extracellular
Other Genes

Source: Ported to COMBREX by Segre's Lab