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Gene ssb from Escherichia coli str. K-12 substr. MG1655: single-stranded DNA-binding protein
Member of NCBI Protein Clusters PRK09010(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948570
UniProtKB accession
RefSeq Protein accession NP_418483.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ssb
  • locus tag: b4059
  • aliases: ECK4051, JW4020, exrB, lexC
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction single-stranded DNA-binding protein
COMBREX ssb single-stranded DNA-binding protein (source organism: Proteus mirabilis; strain specific ID: NCBI_TaxID=584) [More information on this prediction]
Source References Functional description
[PMID: 6270666]
[PMID: 7042342]
[PMID: 6363409]
[PMID: 3301414]
[PMID: 16549871]
[PMID: 9192620]
[PMID: 10932248]
Single-stranded DNA-binding protein (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0006260 : DNA replication : IEA
  • BP: GO:0006974 : response to DNA damage stimulus : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • BP: GO:0000725 : recombinational repair : TAS
  • BP: GO:0006310 : DNA recombination : TAS
  • MF: GO:0003697 : single-stranded DNA binding : IEA
  • BP: GO:0009432 : SOS response : TAS
  • BP: GO:0006298 : mismatch repair : TAS
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0003697 : single-stranded DNA binding : IDA
Domain Structure from CDD
  • SSB_OBF: SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03842 , EcolC_3968 , ECP_4287 , ECs5041 , ECSE_4353 , Ent638_0262 , exrB , NT01EI_3536 , SG2128 , SPAB_05240 , Spro_4439 , ssb (45) , ssb2 (5) , SSPA3781 , YPA_3960 , YPDSF_3647 , YPK_3850 , YPN_3345 , YPTS_0403
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
ftsHprotease, ATP-dependent zinc-metallo
obgEGTPase involved in cell partioning and DNA repair
rpsR30S ribosomal subunit protein S18
tsfprotein chain elongation factor EF-Ts
lepAback-translocating Elongation Factor EF4, GTPase
rpsP30S ribosomal subunit protein S16
acpPacyl carrier protein (ACP)
rluD23S rRNA pseudouridine synthase; specific to U1911
pthpeptidyl-tRNA hydrolase
tufBprotein chain elongation factor EF-Tu (duplicate o
aspSaspartyl-tRNA synthetase
yidCmembrane protein insertase
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-
tufAprotein chain elongation factor EF-Tu (duplicate o
rplS50S ribosomal subunit protein L19
rplQ50S ribosomal subunit protein L17
prfApeptide chain release factor RF-1
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N
rpmG50S ribosomal subunit protein L33
rluApseudouridine synthase for 23S rRNA (position 746)
rpmI50S ribosomal subunit protein L35
rplL50S ribosomal subunit protein L7/L12
rpmA50S ribosomal subunit protein L27
frrribosome recycling factor
rncRNase III
truCtRNA U65 pseudouridine synthase
rluC23S rRNA pseudouridine synthase; specific to U955,
rplI50S ribosomal subunit protein L9
rpsF30S ribosomal subunit protein S6
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methylt
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(not essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)