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Gene priB from Escherichia coli str. K-12 substr. MG1655: primosomal protein N
Member of NCBI Protein Clusters PRK02801(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948722
UniProtKB accession
RefSeq Protein accession NP_418622.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: priB
  • locus tag: b4201
  • aliases: ECK4197, JW4159
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction primosomal replication protein N
Source References Functional description
[PMID: 1856227]
[PMID: 1646811]
[PMID: 8366072]
[PMID: 8663106]
Primosomal replication protein n (source organism: Escherichia coli (strain K12).; strain specific ID: K12)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0006260 : DNA replication : IEA
  • BP: GO:0006269 : DNA replication, synthesis of RNA primer : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0003697 : single-stranded DNA binding : IEA
  • CC: GO:0005658 : alpha DNA polymerase:primase complex : IEA
Domain Structure from CDD
  • SSB_OBF: SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03631 , EcolC_3812 , ECP_4446 , ECs5177 , ECSE_4500 , Ent638_0372 , ESA_00201 , priB (31) , SARI_03240 , SSPA3909
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
rpsR30S ribosomal subunit protein S18
rpsF30S ribosomal subunit protein S6
rplI50S ribosomal subunit protein L9
yebSinner membrane protein 
pqiAparaquat-inducible membrane protein A 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(not essential)
PMID: 20029369
(not essential)