The Gold Standard Gene Database (GSGD), initiated by COMBREX and carried
out in partnership with UniProt and NCBI, aims to identify and collect
information about genes and proteins for which the biochemical function
has been experimentally determined. Such a database, when complete, will
make it easier to distinguish genes whose function has been experimentally
determined from those whose function has merely been assumed or predicted
based on sequence or structural similarity.
Standards for inclusion in GSGD are rigorous, and require all of the following: (1) a known DNA sequence coding for the validated protein, (2) a record of the species and strain of the organism from which the validated protein was isolated or gene cloned, and (3) a published reference to the experimental determination of function.
Construction of the GSGD can only be accomplished through a large manual
curation effort. Exhaustive identification of potential Gold Standard
genes from the vast archive of scientific literature is beyond the
resources of any one group. We are therefore soliciting the help of
scientists to assist us in a massively parallel effort.
The GSGD is currently visible to the pubic only within COMBREX, where genes accepted for inclusion in the GSGD are marked as "Gold" in the Gene Status field. The set of "Gold" genes can be queried using the Advanced Search function by selecting "Gold" from the Gene Status drop-down menu and performing a search as you otherwise would (using keyword, gene name and/or species criteria). If you come across any gene in COMBREX that you believe should be part of the GSGD but is not currently marked with "Gold" status, we strongly encourage you to nominate it for inclusion in GSGD.
To nominate a gene for inclusion in the GSGD, you will need the UniProt
accession number, which can be found either through UniProt (www.uniprot.org)
or through COMBREX, as follows. (If you already know the UniProt number,
or have found it through the UniProt website, skip to step 5 below.)
Richard J. Roberts (New England Biolabs and COMBREX) – firstname.lastname@example.org
William Klimke (NCBI) – email@example.com
Maria Martin (UniProt) – firstname.lastname@example.org