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Genes in Category A-C and Emerging/Re-Emerging pathogens

Genes in curated Protein Clusters

Genes with predictions submitted to COMBREX P

Genes with solved structures in PDB S

Genes with Pfam domains shared with human proteins H

Genes with products purified by PSI U

Genes cloned by PSI C

The good news is that COMBREX has successfully funded many grants to biochemists in its initial phase. The bad news is that our initial allocation of grant money has now been completely utilized. Regrettably, we must suspend funding of further grants until our own funding is renewed. We anticipate this is a temporary situation, as we are sending renewal applications to NIH and continue our strong interest in funding additional COMBREX grants in the near future.

In the meantime, we encourage interested laboratories to send us an email with a short (one or two paragraph) description of your project and this information will be highly helpful in our renewal application. Your full application would be placed at the top of our application stack upon renewal. We also continue to seek submission of predictions from computational prediction teams.

Many thanks for your continued support.

• Join the COMBREX community. COMBREX is a multifaceted project that aims to bring together the computational and experimental communities of biologists in the interest of improving our understanding of microbial gene function.
  
  • Learn more about the COMBREX project.
  • Become a member.
    
    
• Apply for a grant. COMBREX previously offered small monetary grants for biochemists to experimentally verify predicted functions of bacterial and archaeal gene products. We anticipate being able to offer such grants again in the near future. In the meantime, thanks for your patience, and check back often.
  • Learn more about our grants.
  • View the teams we have already funded.
    
    
• Post gene function predictions. COMBREX serves as a forum for computational biologists to post their most informative gene function predictions. Biochemists can then browse these predictions, and may choose to test some of them experimentally.
  • Learn more about submitting predictions.
  • Upload functional predictions.
  • View the teams that have already submitted functional predictions.
    
    
• Search our database. Our evolving database currently includes experimentally determined and computationally predicted functions for more than three million microbial genes.
  • Learn more about navigating the database.
  • Start searching – our search engine is in the green box above.

A list of 100 microbial genes, with predicted functions, most in need of experimental validation. Show List

A list of gene products experimentally characterized using COMBREX funding. Show list.