Gene SSO0016 from Sulfolobus solfataricus P2: transcription regulator (exsB) related protein
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Member of NCBI Protein Clusters
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CLSK883593(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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1455274
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UniProtKB accession
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RefSeq Protein accession
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NP_341593.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: SSO0016
- locus tag: SSO0016
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Organism
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Sulfolobus solfataricus P2 (NCBI TaxID: 273057)
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Other Cross References:
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S Structure(s) available in PDB:
C Gene cloned by a participant in the Protein Structure Initiative (PSI):
TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
U Protein purified by a participant in the Protein Structure Initiative (PSI):
TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
- Protein described in EcoCyc:
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Source
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Predicted function(s)
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NCBI Protein Cluster Prediction
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exsB protein
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References |
Functional description |
| COMBREX |
Under Review
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Archaeosine biosynthesis / COMBREX-validated |
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Functional Status
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Green (experimental evidence, uncurated)
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GO terms
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BP:
GO:0008616 : queuosine biosynthetic process : IEA
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MF:
GO:0000166 : nucleotide binding : IEA
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MF:
GO:0046872 : metal ion binding : IEA
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MF:
GO:0016874 : ligase activity : IEA
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MF:
GO:0005524 : ATP binding : IEA
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MF:
GO:0016810 : hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds : IEA
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BP:
GO:0006541 : glutamine metabolic process : IEA
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Domain Structure from CDD
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- ExsB: ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In Rhizobium meliloti, a species in which the exo genes make succinoglycan, a symbiotically important exopolysaccharide, exsB is located nearby and affects succinoglycan levels, probably through polar effects on exsA expression or the same polycistronic mRNA. In Arthrobacter viscosus, the homologous gene is designated ALU1 and is associated with an aluminum tolerance phenotype. The function is unknown.... (More)
- Gn_AT_II: Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to members of the Ntn (N-terminal nucleophile) hydrolase superfamily and is found at the N-terminus of enzymes such as glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). GLMS catalyzes the formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine in amino sugar synthesis. GPATase catalyzes the first step in purine biosynthesis, an amide transfer from glutamine to PRPP, resulting in phosphoribosylamine, pyrophosphate and glutamate. Asparagine synthetase B synthesizes asparagine from aspartate and glutamine. Beta-LS catalyzes the formation of the beta-lactam ring in the beta-lactamase inhibitor clavulanic acid. GltS synthesizes L-glutamate from 2-oxoglutarate and L-glutamine. These enzymes are generally dimers, but GPATase also exists as a homotetramer..... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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