COMBREX: BCAL3494 in Burkholderia cenocepacia J2315

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Gene BCAL3494 from Burkholderia cenocepacia J2315: type III restriction-modification system methylase

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Summary

Member of NCBI Protein Clusters	CLSK904033(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID	6933247
UniProtKB accession	B4E6M4
RefSeq Protein accession	YP_002232596.1 (PROVISIONAL)
Gene Symbol(s)	symbol: BCAL3494 locus tag: BCAL3494
Organism	Burkholderia cenocepacia J2315 (NCBI TaxID: 216591)

Actions You Can Take

	Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
	Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
	Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
	Post a comment about this gene to appear on this page (info).

Function Predictions

Source	Predicted function(s)
NCBI Protein Cluster Prediction	type III DNA modification methyltransferase

Experimental Validation

Source	References	Functional description
COMBREX	Under Review	DNA methyltransferase M.BceJI (type III RM) modifying CACm6AG / COMBREX-validated
GSDB	[PMID: 19846593]	M.BceJI, Type III N6-adenine DNA methyltransferase (M) subunit recognizing CACAG (source organism: Burkholderia cenocepacia; strain specific ID: J2315)

Supporting Functional Information

Functional Status	Green (experimental evidence, uncurated)
EC number	2.1.1.72 (See reaction via BRENDA) (Source: BRENDA) 2.1.1.72 (See reaction via BRENDA) (Source: NCBI RefSeq)
GO terms	MF: GO:0008168 : methyltransferase activity : IEA MF: GO:0008170 : N-methyltransferase activity : IEA MF: GO:0009007 : site-specific DNA-methyltransferase (adenine-specific) activity : IEA MF: GO:0003676 : nucleic acid binding : IEA BP: GO:0006306 : DNA methylation : IEA MF: GO:0016740 : transferase activity : IEA BP: GO:0032259 : methylation : IEA MF: GO:0003677 : DNA binding : IEA
Domain Structure from CDD	COG2189: Adenine specific DNA methylase Mod [DNA replication, recombination, and repair] See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	N6_N4_Mtase See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details)	[Download ] Bamb_0020 , BamMC406_0029 , Bcen_0042 , Bcen2424_0028 , Bcenmc03_0047 , Bcep1808_0038 , Bcep18194_A3213 , Bmul_0029 , mod