Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene nrdB from Mycobacterium tuberculosis H37Rv: ribonucleotide-diphosphate reductase subunit beta

Hide | Top

Summary
Member of NCBI Protein Clusters PRK08326(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 886699
UniProtKB accession
RefSeq Protein accession NP_214747.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: nrdB
  • locus tag: Rv0233
Organism Mycobacterium tuberculosis H37Rv (NCBI TaxID: 83332)
Other Cross References:
  • S
    Structure(s) available in PDB: 3EE4 3EE4
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:

Hide | Top

Actions You Can Take
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).

Hide | Top

Function Predictions
Source Predicted function(s)
NCBI Protein Cluster Prediction ribonucleotide-diphosphate reductase subunit beta

Hide | Top

Supporting Functional Information
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number 1.17.4.1 (See reaction via BRENDA)) (Source: NCBI RefSeq)
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green nrdB from Escherichia coli str. K-12 substr. MG1655

to see the rest 2 gene click here
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0046914 : transition metal ion binding : IEA
  • MF: GO:0004748 : ribonucleoside-diphosphate reductase activity : IEA
  • BP: GO:0009186 : deoxyribonucleoside diphosphate metabolic process : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
Domain Structure from CDD
  • RNRR2_Rv0233_like: Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain. Rv0233 is a Mycobacterium tuberculosis ribonucleotide re.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database

Hide | Top

Pathway Information