Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
Genes with solved structures in PDB
Genes with Pfam domains shared with human proteins
Genes with products purified by PSI
Genes cloned by PSI
close options


Gene TM0542 from Thermotoga maritima MSB8: malate oxidoreductase
Member of NCBI Protein Clusters CLSK875209(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 897596
UniProtKB accession
RefSeq Protein accession NP_228352.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: TM0542
  • locus tag: TM0542
Organism Thermotoga maritima MSB8 (NCBI TaxID: 243274)
Other Cross References:
  • S
    Structure(s) available in PDB: 1VL6 2HAE
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction malate dehydrogenase
Source References Functional description
COMBREX Under Review Malate dehydrogenase / COMBREX-validated
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0051287 : NAD or NADH binding : IEA
  • MF: GO:0016616 : oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0005488 : binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
Domain Structure from CDD
  • malic: Malic enzyme, N-terminal domain.
  • NAD_bind_2_malic_enz: NAD(P) binding domain of malic enzyme (ME), subgroup 2. Malic enzyme (ME), a member of the amino acid dehydrogenase (DH).... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database