Gene HP0727 from Helicobacter pylori 26695: transcriptional regulator, putative
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Member of NCBI Protein Clusters
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CLSK872423(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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898757
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UniProtKB accession
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RefSeq Protein accession
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NP_207521.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: HP0727
- locus tag: HP0727
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Other Cross References:
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S Structure(s) available in PDB:
C Gene cloned by a participant in the Protein Structure Initiative (PSI):
TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
U Protein purified by a participant in the Protein Structure Initiative (PSI):
TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
- Protein described in EcoCyc:
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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BLASTP hits to experimentally validated proteins
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other hits with E-value < 1e-05
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Share the same Pfam domain composition with the following experimentally validated proteins
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to see the rest 3 genes click here
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GO terms
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BP:
GO:0055114 : oxidation reduction : IEA
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MF:
GO:0003824 : catalytic activity : IEA
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BP:
GO:0008033 : tRNA processing : IEA
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BP:
GO:0008152 : metabolic process : IEA
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MF:
GO:0017150 : tRNA dihydrouridine synthase activity : IEA
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MF:
GO:0050660 : FAD binding : IEA
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MF:
GO:0016491 : oxidoreductase activity : IEA
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Domain Structure from CDD
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- DUS_like_FMN: Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. 1VHN, a putative flavin oxidoreductase, has high sequence similarity to DUS. The enzymatic mechanism of 1VHN is not known at the present..... (More)
- COG0042: tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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