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Gene HP1299 from Helicobacter pylori 26695: methionine aminopeptidase
Member of NCBI Protein Clusters PRK05716(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898824
UniProtKB accession
RefSeq Protein accession NP_208091.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1299
  • locus tag: HP1299
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction methionine aminopeptidase
Prof. Vitkup / Confidence:0.002 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0031625 ubiquitin protein ligase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004177 aminopeptidase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008235 metalloexopeptidase activity / (References: 19435885)
Berkeley Phylogenomics Group Methionyl aminopeptidase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003677 DNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0070006 metalloaminopeptidase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003700 transcription factor activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green mapA from Bacillus subtilis subsp. subtilis str. 168
(%_identity=42.97; E_val=1e-57; BitScore=218.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green map from Escherichia coli str. K-12 substr. MG1655

to see the rest 7 genes click here
GO terms
  • BP: GO:0009987 : cellular process : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0008235 : metalloexopeptidase activity : IEA
  • MF: GO:0004177 : aminopeptidase activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • BP: GO:0006508 : proteolysis : IEA
  • MF: GO:0008233 : peptidase activity : IEA
Domain Structure from CDD
  • MetAP1: Methionine Aminopeptidase 1. E.C. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release o.... (More)
  • PRK07281: methionine aminopeptidase; Reviewed

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
infAtranslation initiation factor IF-1
rplO50S ribosomal protein L15
secYpreprotein translocase subunit SecY
rpmJ50S ribosomal protein L36 
tmkthymidylate kinase  
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)