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Gene HP0745 from Helicobacter pylori 26695: hypothetical protein
Member of NCBI Protein Clusters CLSK872435(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898915
UniProtKB accession
RefSeq Protein accession NP_207538.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0745
  • locus tag: HP0745
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction ribosomal large subunit pseudouridine synthase D
Prof. David Horn 5.4.99: Intramolecular transferase (of other groups) / (References: 20034383)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green rluD from Escherichia coli str. K-12 substr. MG1655
(%_identity=28.08; E_val=6e-26; BitScore=113.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green rsuA from Escherichia coli str. K-12 substr. MG1655

to see the rest 6 genes click here
GO terms
  • MF: GO:0009982 : pseudouridine synthase activity : IEA
  • MF: GO:0003723 : RNA binding : IEA
  • BP: GO:0001522 : pseudouridine synthesis : IEA
  • BP: GO:0009451 : RNA modification : IEA
  • MF: GO:0016853 : isomerase activity : IEA
Domain Structure from CDD
  • RluA: Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]
  • S4: N/A. hypothetical protein; Provisional
  • PseudoU_synth_RluCD_like: PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP0746hypothetical protein
trmBtRNA (guanine-N(7)-)-methyltransferase
rpmA50S ribosomal protein L27 
aspSaspartyl-tRNA synthetase 
rplQ50S ribosomal protein L17 
HP1069cell division protein (ftsH) 
frrribosome recycling factor 
rplS50S ribosomal protein L19 
rpsP30S ribosomal protein S16 
HP1245single-stranded DNA-binding protein 
prfApeptide chain release factor 1 
HP1497peptidyl-tRNA hydrolase 
HP0355GTP-binding protein LepA 
HP1450putative inner membrane protein translocase compon 
HP0286cell division protein (ftsH) 
rplL50S ribosomal protein L7/L12 
rncribonuclease III 
HP13481-acyl-glycerol-3-phosphate acyltransferase (plsC) 
fmtmethionyl-tRNA formyltransferase 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)