Gene HP0745 from Helicobacter pylori 26695: hypothetical protein
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Member of NCBI Protein Clusters
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CLSK872435(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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898915
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UniProtKB accession
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RefSeq Protein accession
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NP_207538.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: HP0745
- locus tag: HP0745
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Source
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Predicted function(s)
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NCBI Protein Cluster Prediction
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ribosomal large subunit pseudouridine synthase D
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Prof. David Horn
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5.4.99: Intramolecular transferase (of other groups) /
(References: 20034383)
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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BLASTP hits to experimentally validated proteins
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other hits with E-value < 1e-05
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Share the same Pfam domain composition with the following experimentally validated proteins
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to see the rest 6 genes click here
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GO terms
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MF:
GO:0009982 : pseudouridine synthase activity : IEA
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MF:
GO:0003723 : RNA binding : IEA
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BP:
GO:0001522 : pseudouridine synthesis : IEA
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BP:
GO:0009451 : RNA modification : IEA
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MF:
GO:0016853 : isomerase activity : IEA
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Domain Structure from CDD
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- RluA: Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]
- S4: N/A. hypothetical protein; Provisional
- PseudoU_synth_RluCD_like: PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli. .... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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| | HP0746 | hypothetical protein | | | | trmB | tRNA (guanine-N(7)-)-methyltransferase | | | | rpmA | 50S ribosomal protein L27 | | | | aspS | aspartyl-tRNA synthetase | | | | rplQ | 50S ribosomal protein L17 | | | | HP1069 | cell division protein (ftsH) | | | | frr | ribosome recycling factor | | | | rplS | 50S ribosomal protein L19 | | | | rpsP | 30S ribosomal protein S16 | | | | HP1245 | single-stranded DNA-binding protein | | | | prfA | peptide chain release factor 1 | | | | HP1497 | peptidyl-tRNA hydrolase | | | | HP0355 | GTP-binding protein LepA | | | | HP1450 | putative inner membrane protein translocase compon | | | | HP0286 | cell division protein (ftsH) | | | | rplL | 50S ribosomal protein L7/L12 | | | | rnc | ribonuclease III | | | | HP1348 | 1-acyl-glycerol-3-phosphate acyltransferase (plsC) | | | | fmt | methionyl-tRNA formyltransferase | | |
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| Phenotype |
Description |
Expression
Class |
Reference(s) |
| Candidate essential gene |
Identified as essential gene in one or more studies (see references) |
Knock out |
(candidate essential)
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