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Functional Status	blue (function predicted, no experimental evidence)
Source of prediction	NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins	This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins	obgE from Caulobacter crescentus CB15 obgE from Escherichia coli str. K-12 substr. MG1655 to see the rest 2 gene click here
GO terms	MF: GO:0000166 : nucleotide binding : IEA CC: GO:0005737 : cytoplasm : IEA CC: GO:0005622 : intracellular : IEA MF: GO:0005525 : GTP binding : IEA MF: GO:0003924 : GTPase activity : IEA
Domain Structure from CDD	Obg: Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain..... (More) GTP1_OBG: GTP1/OBG. The N-terminal domain of the Spo0B-associated GTP-binding protein has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together..... (More) Obg_CgtA: Obg family GTPase CgtA. This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal..... (More) See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	GTP1_OBG H MMR_HSR1 H See domain structure on Pfam Database

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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com

HP0305 hypothetical protein     HP0301 dipeptide ABC transporter, ATP-binding protein (dp     HP0302 dipeptide ABC transporter, ATP-binding protein (dp     HP0304 hypothetical protein     aspS aspartyl-tRNA synthetase     rplQ 50S ribosomal protein L17     HP1497 peptidyl-tRNA hydrolase     rnc ribonuclease III     rplS 50S ribosomal protein L19     HP1069 cell division protein (ftsH)     rplL 50S ribosomal protein L7/L12     rpmA 50S ribosomal protein L27     HP1450 putative inner membrane protein translocase compon     rpsP 30S ribosomal protein S16     HP0286 cell division protein (ftsH)     fmt methionyl-tRNA formyltransferase     frr ribosome recycling factor     HP0355 GTP-binding protein LepA     HP1245 single-stranded DNA-binding protein     prfA peptide chain release factor 1