Gene HP0731 from Helicobacter pylori 26695: hypothetical protein
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Member of NCBI Protein Clusters
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CLSK872427(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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899325
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UniProtKB accession
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RefSeq Protein accession
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NP_207525.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: HP0731
- locus tag: HP0731
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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BLASTP hits to experimentally validated proteins
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This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
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GO terms
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MF:
GO:0005525 : GTP binding : IEA
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MF:
GO:0003924 : GTPase activity : IEA
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Domain Structure from CDD
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- Era_like: Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family..... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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