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Gene mnmA from Helicobacter pylori 26695: tRNA-specific 2-thiouridylase MnmA
Member of NCBI Protein Clusters PRK00143(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899968
UniProtKB accession
RefSeq Protein accession NP_208127.2 (PROVISIONAL)
Gene Symbol(s)
  • symbol: mnmA
  • locus tag: HP1335
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction tRNA-specific 2-thiouridylase MnmA
Berkeley Phylogenomics Group GO:0003921 GMP synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004055 argininosuccinate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019899 enzyme binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003922 GMP synthase (glutamine-hydrolyzing) activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
BLASTP hits to experimentally validated proteins
green mnmA from Escherichia coli str. K-12 substr. MG1655
(%_identity=36.54; E_val=3e-51; BitScore=197.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green mnmA from Streptococcus pneumoniae TIGR4

to see the rest 2 gene click here
GO terms
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • BP: GO:0008033 : tRNA processing : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0006400 : tRNA modification : IEA
  • MF: GO:0000049 : tRNA binding : IEA
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0016740 : transferase activity : IEA
Domain Structure from CDD
  • tRNA_Me_trans: tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is invol.... (More)
  • trmU: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransfera.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
rpsP30S ribosomal protein S16
HP1245single-stranded DNA-binding protein
aspSaspartyl-tRNA synthetase
rplQ50S ribosomal protein L17
rncribonuclease III
rplS50S ribosomal protein L19
HP1069cell division protein (ftsH)
prfApeptide chain release factor 1
HP1497peptidyl-tRNA hydrolase
rplL50S ribosomal protein L7/L12
rpmA50S ribosomal protein L27
HP0355GTP-binding protein LepA
HP1450putative inner membrane protein translocase compon
HP0286cell division protein (ftsH)
fmtmethionyl-tRNA formyltransferase
frrribosome recycling factor